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Generic name: digoxin immune FABdi-JOX-in-im-MYOON-FAB ]
Drug class: Antidotes

Medically reviewed by on Sep 14, 2023. Written by Cerner Multum.

What is DigiFab?

DigiFab is used as an antidote to treat a life-threatening overdose of digoxin or digitoxin.

DigiFab is not for treating a mild digitalis overdose.

DigiFab may also be used for purposes not listed in this medication guide.

DigiFab side effects

Get emergency medical help if you have signs of an allergic reaction: hives, itching, skin redness; wheezing, cough, difficult breathing; fast heartbeats, feeling light-headed; swelling of your face, lips, tongue, or throat.

Tell your caregivers right away if you have:

Common side effects of DigiFab may include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


If possible, before you receive DigiFab, tell your doctor if you have heart disease or kidney disease, or if you are allergic to antibiotics, papaya, or pineapple.

Before taking this medicine

If possible before you receive DigiFab, tell your caregivers if you have:

In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received DigiFab.

How is DigiFab given?

DigiFab is given as an infusion into a vein. A healthcare provider will give you this injection.

Your breathing, blood pressure, oxygen levels, kidney function, and other vital signs will be watched closely.

Medical tests will help your doctor determine how long to treat you with DigiFab.

What happens if I miss a dose?

Since DigiFab is given in an emergency situation by a healthcare professional, it is not likely that you will miss a dose.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving DigiFab?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

What other drugs will affect DigiFab?

Other drugs may affect DigiFab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.