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Aflibercept ophthalmic

Generic Name: aflibercept ophthalmic (a FLIB er sept off THAL mik)
Brand Name: Eylea

Medically reviewed on August 1, 2017.

What is aflibercept ophthalmic?

Aflibercept is made from a human antibody fragment. It works by keeping new blood vessels from forming under the retina (a sensory membrane that lines the inside of the eye). In people with a certain type of eye disease, new blood vessels grow under the retina where they leak blood and fluid. This is known as the "wet form" of macular degeneration.

Aflibercept ophthalmic (for the eyes) is used to treat wet age-related macular degeneration. Aflibercept is also used to treat swelling in the retina caused by a blockage in the blood vessels.

Aflibercept ophthalmic is also used to treat diabetic retinopathy, an eye disorder in diabetics that can lead to a buildup of fluid in the retina and cause blindness.

Aflibercept ophthalmic may also be used for purposes not listed in this medication guide.

Important Information

You should not use aflibercept if you have swelling inside your eyes, or any type of infection in or around your eyes.

Call your doctor at once if you have eye pain or redness, swelling or puffiness around your eyes, or sudden vision problems at any time during treatment.

Before taking this medicine

You should not use aflibercept if you are allergic to it, or if you have:

  • swelling inside your eyes; or

  • any type of infection (bacterial, fungal, viral) in or around your eyes.

To make sure aflibercept is safe for you, tell your doctor if you have ever had:

  • a blood clot or stroke; or

  • glaucoma or other condition that increase pressure inside your eyes.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy before your first dose of this medicine. Keep using birth control for at least 3 months after your last injection.

It is not known whether aflibercept passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine.

How is aflibercept ophthalmic given?

Aflibercept ophthalmic is given as an injection into your eye. Your doctor will use a medicine to numb your eye before giving you the injection. You will receive this injection in your doctor's office or other clinic setting.

For a short time after your injection, your eyes will be checked periodically to make sure the injection has not caused any side effects.

Aflibercept is usually given once every 4 weeks for the first 3 months, and then once every 8 weeks. Follow your doctor's dosing instructions very carefully.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your aflibercept injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while using aflibercept ophthalmic?

This medication may cause blurred vision. Be careful if you drive or do anything that requires you to be able to see clearly.

Aflibercept ophthalmic side effects

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your eyes, face, lips, tongue, or throat.

Call your doctor at once if you have:

  • eye pain or redness, swelling around your eyes;

  • sudden vision problems;

  • seeing flashes of light or "floaters" in your vision, seeing halos around lights;

  • increased sensitivity of your eyes to light;

  • sudden numbness or weakness, especially on one side of the body; or

  • sudden severe headache, confusion, problems with speech or balance.

Common side effects may include:

  • red or watery eyes;

  • blurred vision;

  • swelling of the eyelids; or

  • mild eye pain or discomfort after the injection.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Aflibercept ophthalmic dosing information

Usual Adult Dose for Macular Degeneration:

Neovascular (Wet) Age Related Macular Degeneration (AMD):
2 mg (0.05 mL) administered by intravitreal injection every 4 weeks (monthly) for the first 12 weeks (3 months), followed by 2 mg (0.05 mL) via intravitreal injection once every 8 weeks (2 months).

Comments: Additional efficacy was not demonstrated when dosed every 4 weeks compared to every 8 weeks.

Usual Adult Dose for Macular Edema:

Macular edema following retinal vein occlusion (RVO):
2 mg (0.05 mL) administered by intravitreal injection once every 4 weeks (monthly).

Diabetic Macular Edema (DME)/Diabetic Retinopathy (DR) in Patients with DME:
2 mg (0.05 mL) administered by intravitreal injection every 4 weeks (monthly) for the first 5 injections, followed by 2 mg (0.05 mL) via intravitreal injection once every 8 weeks (2 months).

Comments: Additional efficacy was not demonstrated when dosed every 4 weeks compared to every 8 weeks.

What other drugs will affect aflibercept ophthalmic?

It is not likely that other drugs you take orally or inject will have an effect on aflibercept used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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