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Sumatriptan (Monograph)

Brand names: Alsuma, Imitrex, Sumavel
Drug class: Selective Serotonin Agonists
- Antimigraine Agents
- Selective Vascular Serotonin Type 1-Like Receptor Agonists
- 5-HT1 Agonists
VA class: CN105
Chemical name: C14H21N3O2S
Molecular formula: C14H21N3O2S•C4H6O4
CAS number: 103628-46-2

Medically reviewed by Drugs.com on Nov 11, 2024. Written by ASHP.

Introduction

Selective serotonin (5-hydroxytryptamine; 5-HT) type 1B and 1D receptor agonist (“triptan”).1 2 3 4 5 6 7 8 223 224 268

Uses for Sumatriptan

Vascular Headaches

Acute treatment of migraine attacks with or without aura.1 2 3 6 7 8 9 10 13 48 80 145 148 184 195 214 217 225 249 279 280

Sub-Q for acute treatment of cluster headache episodes.1 2 49 75 183 184 185 210 214 279 280 Safety and efficacy of oral or intranasal sumatriptan for this use not established.148 249

Not recommended for management of hemiplegic or basilar migraine or for prophylaxis of migraine or cluster headache.1 7 114 158

Sumatriptan Dosage and Administration

Administration

Administer orally, intranasally, or by sub-Q injection.1 12 148 249 Do not administer IM or IV; IV administration may induce coronary vasospasm.1 13 40 90 236 237 279 280 Has been administered as an iontophoretic transdermal system; however, marketing was suspended because of serious application site reactions.286 287 (See Local Effects under Cautions.)

To achieve maximum relief, initiate therapy as soon as possible after onset of migraine attack.50 92 108 124 148 180 237

Oral Administration

Administer sumatriptan tablets orally with fluids; swallow tablet whole.148

Administer sumatriptan/naproxen fixed-combination tablets with or without food; do not split, crush, or chew.281

Intranasal Administration

Administer intranasally as a single spray into 1 nostril.249

Nasal solution unit contains only 1 spray; do not test before use.249

To administer, remove unit from package just before use.249 While sitting down, gently blow nose to clear nasal passages.249 Keep head in upright position and gently close 1 nostril with index finger; exhale gently through mouth.249 With other hand, hold unit with thumb supporting at bottom and index and middle fingers on either side of nozzle.249 Insert nozzle into open nostril about ½ inch.249 While gently inhaling through nose (with closed mouth), release spray by firmly pressing plunger.249 Remove nozzle from nostril while keeping head level for 10–20 seconds and gently inhaling through nose and exhaling through mouth; do not inhale deeply.249 Consult administration instructions provided by manufacturer before use.249

Sub-Q Administration

Administer only by sub-Q injection.1 279 280

Do not administer IM or IV; IV administration may induce coronary vasospasm.1 13 40 90 236 237 279 280

Autoinjection devices are available to facilitate self-administration of 4- or 6-mg dose.1 279 280

Injection pen for use with prefilled cartridges (each containing a 4- or 6-mg dose): Needle penetrates approximately 5–6 mm (¼ inch); use injection sites with an adequate skin and subcutaneous thickness to accommodate needle length (e.g., lateral thigh, upper arm).1 284

Prefilled injection pen (containing 6-mg dose): Needle projects ¼ inch following activation of device; use injection sites with an adequate skin and subcutaneous thickness to accommodate needle length (e.g., lateral thigh, upper arm).279

Prefilled needleless injection device (containing 6-mg dose): Use administration sites on abdomen (avoiding 2-inch area around the umbilicus) or thigh with an adequate subcutaneous thickness to accommodate penetration of the solution into the subcutaneous space.280 Avoid using administration sites on upper arm, since delivered dose may be suboptimal.280

In patients receiving doses other than 4 or 6 mg, only the single-dose vials containing 6 mg/0.5 mL should be used to provide the desired dose.1

Dosage

Available as sumatriptan (nasal solution) and sumatriptan succinate (tablets and injection); dosage expressed in terms of sumatriptan.1 148 249

Following failure to respond to first dose, reconsider diagnosis of migraine prior to administration of a second dose.1 148 249

Adults

Vascular Headaches
Migraine
Oral (Sumatriptan)

25, 50, or 100 mg as a single dose.148 Individualize dosage selection, weighing the possible benefit (greater effectiveness) and risks (increased adverse effects) of the 50- or 100-mg dose; 100-mg dose may not provide substantially greater effect than 50-mg dose.148

If headache recurs or partial response occurs after initial dose, additional oral doses may be administered at intervals of ≥2 hours, up to a maximum oral dosage of 200 mg daily.148

If headache recurs after an initial sub-Q dose, additional oral doses may be administered at intervals ≥2 hours, up to a maximum oral dosage of 100 mg daily.148

Oral (Sumatriptan/Naproxen)

Sumatriptan 85 mg (with naproxen sodium 500 mg) as a single dose.281

Efficacy of >1 dose not established.281 If a second dose is administered, allow ≥2 hours to elapse between the first and second doses.281

Intranasal

5, 10, or 20 mg as a single dose; individualize dosage selection, weighing the possible benefit (greater effectiveness) and risks (increased adverse effects) of the 20-mg dose.249 Doses >20 mg provide no additional benefit.249

To achieve a 10-mg dose, administer a single 5-mg dose into each nostril.249

If headache recurs, dose may be repeated once after 2 hours, up to a maximum dosage of 40 mg daily.249

Sub-Q

≤6 mg as a single dose.1 If dose-limiting adverse effects occur with 6-mg dose, lower doses (e.g., 1–5 mg) may be given.

If headache recurs, a 6-mg sub-Q dose may be repeated once after ≥1 hour or additional oral doses may be administered at intervals ≥2 hours, up to a maximum oral dosage of 100 mg daily.1 148

If patient does not respond to first 6-mg dose, additional doses are unlikely to provide benefit.2 3 6 7 8 9 174 176 181 236 237

Cluster Headache
Sub-Q

≤6 mg as a single dose.1 Manufacturers state that efficacy of doses <6 mg not established;1 however, some patients may derive benefit from such lower doses (e.g., 3 mg).13 210 285

If headache recurs, 6-mg dose may be repeated once after ≥1 hour, up to a maximum dosage of 12 mg in any 24-hour period.1

If patient does not respond to first 6-mg dose, additional doses are unlikely to provide benefit.1 2 3 6 7 8 9 174 176 181 236 237

Prescribing Limits

Adults

Vascular Headaches
Migraine
Oral (Sumatriptan)

Maximum 200 mg daily; do not exceed 100 mg daily if following an initial sub-Q dose.148

Safety of treating an average of >4 headaches per 30-day period has not been established.148

Oral (Sumatriptan/Naproxen)

Maximum 2 doses (total sumatriptan dosage of 170 mg) in any 24-hour period.281

Safety of treating an average of >5 headaches per 30-day period has not been established.281

Intranasal

Maximum 40 mg daily.249

Safety of treating an average of >4 headaches per 30-day period has not been established.249

Sub-Q

Maximum 6 mg as a single dose; do not exceed 12 mg (i.e., two 6-mg doses given ≥1 hour apart) in any 24-hour period.1

Cluster Headache
Sub-Q

Maximum 6 mg as a single dose; do not exceed 12 mg (i.e., two 6-mg doses given ≥1 hour apart) in any 24-hour period.1

Special Populations

Hepatic Impairment

Contraindicated in patients with severe hepatic impairment.1 148 249

Unpredictable increases in bioavailability following oral administration in patients with hepatic impairment.148 If oral therapy is deemed advisable in these patients, do not exceed 50 mg as a single dose.148 Avoid use of fixed-combination tablets containing sumatriptan 85 mg and naproxen sodium 500 mg, since sumatriptan dosage cannot be appropriately adjusted.281

Geriatric Patients

Select dosage with caution, usually starting at the low end of the dosage range.1

Detailed Sumatriptan dosage information

Cautions for Sumatriptan

Contraindications

Warnings/Precautions

Careful Diagnosis of Migraine

Use oral or intranasal sumatriptan only in patients in whom a clear diagnosis of migraine has been established.148 249 Use sub-Q sumatriptan only in patients in whom a clear diagnosis of migraine or cluster headache has been established.1

If first migraine attack treated with sumatriptan fails to respond to the drug, reconsider diagnosis before administering sumatriptan to treat subsequent attacks.1

Exclude other potentially serious neurologic disorders before administering sumatriptan to patients not previously diagnosed with migraine or cluster headache or to those with atypical symptoms.1 61 148 236 237 249

Cardiac Effects

Possible myocardial ischemia and/or infarction and coronary vasospasm, even in patients without a history of CAD.1 148 249 Contraindicated in patients with ischemic or vasospastic heart disease.1 148 249

Possible fatal or life-threatening cardiac rhythm disturbances (e.g., ventricular tachycardia or fibrillation).1 148 249 Discontinue if such disturbances occur.1

Contraindicated in patients with Wolff-Parkinson-White syndrome or cardiac arrhythmias associated with other accessory pathway conduction disorders.1

Tightness, pain, pressure, and heaviness in the precordium, throat, neck, and jaw occur frequently but usually are noncardiac in origin.1 148 249 Manufacturer states that cardiovascular evaluation should be performed if patient is at high cardiac risk.1

Patients with symptoms suggestive of angina after receiving sumatriptan should be evaluated for presence of CAD or predisposition to Prinzmetal variant angina before receiving additional doses;1 148 249 if administration resumed and such signs or symptoms recur, ECG evaluation recommended.148 249

Patients at Risk for CAD

Perform cardiovascular evaluation prior to initiating therapy in patients with multiple cardiovascular risk factors (e.g., postmenopausal women; men >40 years of age; patients with risk factors such as hypertension, hypercholesterolemia, smoking, obesity, diabetes, family history of CAD) who have not previously received 5-HT1 receptor agonist therapy.1 34 148 164 249

If evaluation provides evidence of CAD or coronary vasospasm, do not administer the drug.1 148 249

If results of evaluation are satisfactory, consider administering the initial dose in a medically supervised setting followed immediately by an ECG.1 40 148 236 237 249

Periodic cardiovascular evaluation recommended in patients with risk factors for CAD if receiving intermittent long-term therapy.1 148 236 237 249

Cerebrovascular Events

Possible cerebral or subarachnoid hemorrhage and stroke, sometimes fatal.1 148 249 (See Careful Diagnosis of Migraine under Cautions.) Discontinue therapy if a cerebrovascular event occurs.1

Risk of certain cerebrovascular events (e.g., stroke, hemorrhage, TIA) may be increased in patients with migraine.1 148 249

Other Vasospastic Effects

Possible noncoronary vasospastic reactions (e.g., peripheral vascular ischemia, GI ischemia and infarction with abdominal pain and bloody diarrhea, splenic infarction, Raynaud’s syndrome); transient or permanent blindness and partial vision loss reported very rarely in patients receiving 5-HT1 receptor agonists.1 148 249

If signs or symptoms suggestive of vasospasm occur following administration, evaluate patient to rule out vasospastic reaction before administering additional doses.1 6 8 148 249

Hypertensive Effects

Substantial increases in BP, including hypertensive crisis with acute impairment of organ systems, reported rarely in patients with or without history of hypertension.1 148 249

Administer with caution in patients with controlled hypertension as transient increases in BP and peripheral vascular resistance are possible.3 11 148 249 (See Contraindications under Cautions.)

Monitor BP in all patients receiving the drug.1

Serotonin Syndrome

Potentially life-threatening serotonin syndrome reported in patients receiving 5-HT1 receptor agonists, particularly in those receiving SSRIs or SNRIs concomitantly.1 148 249 272 (See Specific Drugs under Interactions.) Also may occur in patients receiving MAO inhibitors or tricyclic antidepressants concomitantly.1

Symptoms may include mental status changes (e.g., agitation, hallucinations, coma), autonomic instability (e.g., tachycardia, labile BP, hyperthermia), neuromuscular aberrations (e.g., hyperreflexia, incoordination), and/or GI symptoms (e.g., nausea, vomiting, diarrhea).1 148 249 272

If manifestations of serotonin syndrome occur, discontinue sumatriptan and any concurrently administered serotonergic agents and initiate supportive and symptomatic treatment.1 148 249 278

Medication Overuse Headache

Overuse of drugs indicated for management of acute migraine attacks (e.g., use of 5-HT1 receptor agonists, ergotamine, opiates, or certain analgesic combinations on a regular basis for ≥10 days per month) may result in migraine-like daily headaches or a marked increase in frequency of migraine attacks.1 148 249 276 277

Detoxification, including withdrawal of overused drugs; treatment of withdrawal symptoms (e.g., transient worsening of headaches); and consideration of prophylactic migraine therapy may be necessary.1 148 249 276 277

Local Effects

Possible transient irritation in nose and throat (e.g., burning, numbness, paresthesia, discharge, pain/soreness), sometimes severe, after intranasal administration; symptoms usually resolve in <2 hours.249 Effects of extended and repeated use on nasal and/or respiratory mucosa not systematically evaluated.249

Burns and scarring reported at application site of sumatriptan iontophoretic transdermal system (Zecuity).286 287 Reactions included severe erythema, cracked skin, blistering or welts, burns or scars, skin discoloration, severe pain, pruritus, and burning sensation.286 287 Many cases resolved within hours to weeks, but some reactions, typically skin discoloration, were unresolved after several months.286 Manufacturer voluntarily suspended marketing of the formulation.286 287

Sensitivity Reactions

Hypersensitivity reactions (e.g., anaphylaxis/anaphylactoid reactions), possibly life-threatening or fatal, reported rarely; increased risk in patients with history of sensitivity to multiple allergens.1 148 249

Seizures

Seizures reported rarely; use with caution in patients with a history of seizures or with conditions associated with a lowered seizure threshold.1 148 249

Ocular Effects

Corneal opacities and corneal epithelial defects reported in dogs.1 148 249

Use of Fixed Combinations

When used in fixed combination with naproxen, consider the cautions, precautions, and contraindications associated with naproxen.281

Specific Populations

Pregnancy

Category C.1 148 249

Lactation

Distributed into human milk.14 40 148 242 249 279 280 283 Caution advised if sumatriptan is used.279 280 Expressing and discarding all milk for 8 hours after receiving a sub-Q dose may minimize exposure to the limited amount of drug distributed into milk.242 283 The manufacturers recommend avoiding breast-feeding for 12 hours after receiving sumatriptan oral tablets or nasal spray.148 249

Pediatric Use

Safety and efficacy not established in children <18 years of age;1 12 148 236 237 249 use not recommended.1 148 249 Serious adverse events reported in children receiving sumatriptan.1 148 249

Geriatric Use

Insufficient experience in patients ≥65 years of age to determine whether geriatric patients respond differently than younger adults.1

Potential for more pronounced increases in BP; consider increased risk for CAD in geriatric patients.1 148 249 (See Cardiac Effects under Cautions.)

Select dosage with caution.1 Consider the greater frequency of decreased hepatic, renal, and/or cardiac function and of concomitant disease and drug therapy observed in the elderly.1

Hepatic Impairment

Contraindicated in patients with severe hepatic impairment.1 148 249

Due to important role of the liver in presystemic clearance of oral sumatriptan, dosage adjustment recommended if oral therapy is deemed advisable in patients with hepatic impairment.148 (See Hepatic Impairment under Dosage and Administration.)

Pharmacokinetics of sub-Q sumatriptan not substantially altered in patients with moderate hepatic impairment.1

Common Adverse Effects

With oral therapy, pain/pressure sensations in chest/neck/throat/jaw, paresthesia, warm or cold sensation, malaise/fatigue, vertigo.148

With intranasal therapy, taste disturbances, nausea, vomiting, disorder/discomfort of nasal cavity or sinuses.249

With sub-Q therapy, injection site reaction; atypical sensations (e.g., tingling, warm/hot sensation, burning, feeling of heaviness, pressure, tightness, numbness, paresthesia); dizziness/vertigo; flushing; discomfort of throat, jaw, sinuses, or nasal cavity; weakness, neck pain/stiffness, myalgia; drowsiness/sedation; headache; sweating; chest discomfort (tightness, pressure); nausea and vomiting.1

Drug Interactions

Metabolized principally by MAO-A isoenzyme in vitro.148

Protein-bound Drugs

Effect on protein binding of other drugs has not been evaluated,1 but expected to be minor due to low-level protein binding of sumatriptan.148 249

Specific Drugs

Drug

Interaction

Comments

Acetaminophen

Pretreatment with oral sumatriptan followed by acetaminophen affected rate, but not extent of acetaminophen absorption over 8 hours187

Alcohol

Administration of alcohol 30 minutes prior to oral sumatriptan did not affect sumatriptan pharmacokinetics44 45 148 236

Amitriptyline

Concomitant use did not affect sumatriptan efficacy40 62

Antidepressants, SSRIs (e.g., citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) and SNRIs (e.g., duloxetine, venlafaxine)

Potentially life-threatening serotonin syndrome1 148 249 272

Observe carefully if used concomitantly, particularly during treatment initiation, dosage increases, or when another serotonergic agent is initiated272

Ergot alkaloids (e.g., ergotamine, dihydroergotamine, methysergide [no longer commercially available in the US])

Additive vasospastic effects1 148 249

Use within 24 hours contraindicated1 148 249

5-HT1receptor agonists

Additive vasospastic effects1 148 249

Use within 24 hours contraindicated1 148 249

MAO inhibitors

MAO-A inhibitors decrease sumatriptan clearance, resulting in substantially increased systemic exposure; no substantial effect on sumatriptan metabolism seen with an MAO-B inhibitor1 148 249

Use within 2 weeks of MAO-A inhibitor contraindicated1 26 37 148 157 236 249

Propranolol

Concomitant use did not affect sumatriptan efficacy;40 62 pretreatment with propranolol did not alter pharmacokinetics or pharmacodynamics of oral sumatriptan62

Verapamil

Concomitant use did not affect sumatriptan efficacy40 62

Xylometazoline

Topical application of xylometazoline to nasal mucosa 15 minutes prior to intranasal sumatriptan did not affect sumatriptan pharmacokinetics249
Sumatriptan drug interactions (more detail)

Sumatriptan Pharmacokinetics

Absorption

Bioavailability

Absorbed rapidly after oral, intranasal, or sub-Q administration, with peak plasma concentrations attained within approximately 0.5–5 hours, 0.8–1.8 hours, or 5–20 minutes, respectively.1 2 3 13 45 61 78 79 89 96 123 146 148 166 168 236 280

Bioavailability after sub-Q administration averages 97% of that obtained with IV administration;1 44 bioavailability after oral or intranasal administration averages only about 15 or 17%, respectively, principally due to presystemic metabolism and in part due to incomplete absorption.2 13 14 44 45 61 89 146 148 166 168 249

Oral absorption is not appreciably affected by gastric stasis that may occur during migraine attack,3 13 45 146 but time to peak concentration is prolonged by about 30 minutes;3 13 45 96 146 148 pharmacokinetics after sub-Q injection or after oral administration in fixed combination with naproxen sodium appear to be similar during migraine attacks and pain-free periods.1 281

Oral administration of sumatriptan 85 mg/naproxen sodium 500 mg (as fixed combination) or sumatriptan 100 mg alone resulted in similar peak concentrations and AUCs of sumatriptan; time to peak concentration was about 30 minutes shorter when administered as the fixed combination.281

Following sub-Q injection via injection pen or manually in deltoid area or thigh, time to peak concentration and amount of drug absorbed was not affected by injection site or technique.1 279

Following sub-Q administration via needleless device at sites on the abdomen or thigh, peak concentrations and time to peak concentrations were similar; administration using this technique at sites on the upper arm may result in delivery of a suboptimal dose.280

Special Populations

In patients with hepatic impairment, bioavailability after oral administration may be markedly increased.148 In a small study, AUC and peak plasma concentrations increased approximately 70% and time to peak plasma concentrations occurred 40 minutes earlier after oral administration compared with such values in healthy adults.13 44 148 236

Moderate hepatic impairment did not alter pharmacokinetics of sub-Q sumatriptan.1 Effect of severe hepatic impairment on pharmacokinetics of sub-Q sumatriptan not established.1

Onset

After oral administration, onset of relief of migraine symptoms generally occurs within 1–3 hours after single doses (25–100 mg),92 148 162 178 191 with maximum pain relief attained within 3–6 hours.148 178 191

After intranasal administration, onset of headache relief occurs within 30 minutes following a 10-, 20-, or 40-mg dose.123 243

After sub-Q administration, onset of pain relief usually occurs within 10–34 minutes in patients with moderate to severe migraine headache pain, with maximum relief attained within 1–2 hours;1 8 9 13 47 56 162 176 181 onset of pain relief generally occurs within 4–7 minutes in patients with cluster headache, with headache resolution shortly thereafter.40 49 75 184

Food

Food does not appreciably affect oral bioavailability, but prolongs time to peak concentration.2 13 44 148 281

Distribution

Extent

Rapidly and widely distributed into body tissues after sub-Q administration.1 14 146 148 168

Distributed into human milk;1 148 only small amounts cross placenta by passive transport in vitro.235

Plasma Protein Binding

Approximately 14–21%.1 14 45 148

Elimination

Metabolism

Metabolized in the liver and possibly in the GI tract principally to inactive indole acetic acid metabolite and other minor metabolites;1 2 3 13 14 104 148 166 metabolized principally by MAO-A isoenzyme in vitro.1 37 48 148

Elimination Route

After oral administration, excreted in urine (57–60%) and feces (37–40%); only 3 and 9% of dose is excreted as unchanged drug in urine and feces, respectively.14 45 148 13 45 148 166 168 After sub-Q administration, approximately 22 or 38–53% of dose is excreted in urine unchanged or as indole acetic acid metabolite, respectively;1 45 168 0.6 and 3.3% of dose is excreted in feces as unchanged drug and indole acetic acid metabolite, respectively.2 13 14 45

Half-life

1.5–2.6 hours.1 6 44 45 78 79 89 91 148 166 168 249 280 281

Special Populations

In patients with renal impairment, pharmacokinetics not evaluated, but little clinical effect expected since drug is largely metabolized to an inactive metabolite.1 148 249

Stability

Storage

Oral

Tablets

Sumatriptan: 2–30°C.148

Sumatriptan/naproxen: 25°C (may be exposed to 15–30°C).281 Store in original container with desiccant packet; do not repackage.281

Intranasal

Solution

2–30°C; protect from light.249

Parenteral

Injection

Cartridge, vial: 2–30°C; protect from light.1

Prefilled injection pen: 25°C (may be exposed to 15–30°C); protect from light; do not refrigerate.279

Prefilled needleless device: 20–25°C (may be exposed to 15–30°C); do not freeze.280

Actions

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

SUMAtriptan

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Nasal

Solution

5 mg/0.1 mL*

Imitrex Nasal Spray

GlaxoSmithKline

SUMAtriptan Nasal Spray

20 mg/0.1 mL*

Imitrex Nasal Spray

GlaxoSmithKline

SUMAtriptan Nasal Spray

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

SUMAtriptan Succinate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets, film-coated

25 mg (of sumatriptan)*

Imitrex

GlaxoSmithKline

SUMAtriptan Succinate Tablets

50 mg (of sumatriptan)*

Imitrex

GlaxoSmithKline

SUMAtriptan Succinate Tablets

100 mg (of sumatriptan)*

Imitrex

GlaxoSmithKline

SUMAtriptan Succinate Tablets

Parenteral

Injection, for subcutaneous use only

4 mg (of sumatriptan) per 0.5 mL*

Imitrex (available in 0.5-mL unit-of-use injection-pen cartridges)

GlaxoSmithKline

SUMAtriptan Succinate Injection (available in 0.5-mL unit-of-use injection-pen cartridges)

6 mg (of sumatriptan) per 0.5 mL*

Alsuma (available in prefilled disposable single-use 0.5-mL injection pen)

Pfizer

Imitrex (available in 0.5-mL unit-of-use injection-pen cartridges and as 0.5-mL single-dose vials)

GlaxoSmithKline

SUMAtriptan Succinate Injection (available in 0.5-mL unit-of-use injection-pen cartridges and as 0.5-mL single-dose vials)

Sumavel (available in prefilled disposable single-use 0.5-mL needleless delivery device)

Zogenix
SUMAtriptan Succinate Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets, film-coated

85 mg (of sumatriptan) with 500 mg Naproxen Sodium

Treximet

GlaxoSmithKline

AHFS DI Essentials™. © Copyright 2025, Selected Revisions November 20, 2017. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

References

1. GlaxoSmithKline. Imitrex (sumatriptan succinate) injection prescribing information. Research Triangle Park, NC; 2012 Oct.

2. Hsu VD. Sumatriptan: a new drug for vascular headache. Clin Pharm. 1992; 11:919-29. https://pubmed.ncbi.nlm.nih.gov/1334452

3. Bateman DN. Sumatriptan. Lancet. 1993; 341:221-4. https://pubmed.ncbi.nlm.nih.gov/8093509

4. Peroutka SJ. Serotonin receptor subtypes and neuropsychiatric diseases: focus on 5-HT1D and 5-HT3 receptor agents. Pharmacol Rev. 1991; 43:579-86. https://pubmed.ncbi.nlm.nih.gov/1663621

5. MacIntyre PD, Bhargava B, Hogg KJ et al. Effect of subcutaneous sumatriptan, a selective 5HT1 agonist, on the systemic, pulmonary, and coronary circulation. Circulation. 1993; 87:401-5. https://pubmed.ncbi.nlm.nih.gov/8381056

6. Fullerton T, Gengo FM. Sumatriptan: a selective 5-hydroxytryptamine receptor agonist for the acute treatment of migraine. Ann Pharmacother. 1992; 26:800-8. https://pubmed.ncbi.nlm.nih.gov/1319244

7. Anon. Sumatriptan for migraine. Med Lett Drugs Ther. 1992; 34:91-3. https://pubmed.ncbi.nlm.nih.gov/1326077

8. Ferrari MD and the Subcutaneous Sumatriptan International Study Group. Treatment of migraine attacks with sumatriptan. N Engl J Med. 1991; 325:316-21. https://pubmed.ncbi.nlm.nih.gov/1647495

9. Cady RK, Wendt JK, Kirchner JR et al. Treatment of acute migraine with subcutaneous sumatriptan. JAMA. 1991; 265:2831-5. https://pubmed.ncbi.nlm.nih.gov/1851894

10. Friberg L, Olesen J, Iversen HK et al. Migraine pain associated with middle cerebral artery dilatation: reversal by sumatriptan. Lancet. 1991; 338:13-7. https://pubmed.ncbi.nlm.nih.gov/1676084

11. Fox AW, Poe TE. Use and safety of sumatriptan. Clin Pharm. 1993; 12:258. https://pubmed.ncbi.nlm.nih.gov/8384541

12. Glaxo, Research Triangle Park, NC: Personal communication.

13. Plosker GL, McTavish D. Sumatriptan: a reappraisal of its pharmacology and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1994; 47:622-51. https://pubmed.ncbi.nlm.nih.gov/7516861

14. Dixon CM, Saynor DA, Andrew PD et al. Disposition of sumatriptan in laboratory animals and humans. Drug Metabol Disp. 1993; 21:761-9.

15. Dechant KL, Clissold SP. Sumatriptan: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 1992; 43:776-98. https://pubmed.ncbi.nlm.nih.gov/1379152

16. D’Arcy PF. Adverse drug reaction (ADR) problems with sumatriptan. Intl Pharm J. 1992; 6:264-5.

17. D’Arcy PF. Warnings from the UK committee on safety of medicines: chest pain with sumatriptan. Intl Pharm J. 1992; 6:217-8.

18. Willett F, Curzen N, Adams J et al. Coronary vasospasm induced by subcutaneous sumatriptan. BMJ. 1992; 304:1415. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1882171/ https://pubmed.ncbi.nlm.nih.gov/1320974

19. Price LH, Charney DS, Delgado PL et al. Lithium treatment and serotoninergic function. Arch Gen Psych. 1989; 46:13-9.

20. Castle WM, Simmons VE. Coronary vasospasm and sumatriptan. BMJ. 1992; 305:117-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1882599/ https://pubmed.ncbi.nlm.nih.gov/1322216

21. Stricker BHC. Coronary vasospasm and sumatriptan. BMJ. 1992; 305:118.

22. Inman W, Kubota K. Cardiorespiratory distress after sumatriptan given by injection. BMJ. 1992; 305:714. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1882911/ https://pubmed.ncbi.nlm.nih.gov/1327369

23. Curtin T, Brooks AP, Roberts JA. Cardiorespiratory distress after sumatriptan given by injection. BMJ. 1992; 305:713-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1882941/ https://pubmed.ncbi.nlm.nih.gov/1327368

24. Pilgrim AJ, Lloyd DK, Simmons VE. Cardiorespiratory distress after sumatriptan given by injection. Br Med J. 1992;305:714. Letter. (IDIS 302439)

25. Lloyd DK, Pilgrim AJ, Simmons VE. Coronary vasospasm and sumatriptan. BMJ. 1992; 305:310-1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1882748/ https://pubmed.ncbi.nlm.nih.gov/1327366

26. Anon. New medicines: sumatriptan. Intl Pharm J. 1992; 6:55-7.

27. Ottervanger JP, Paalman HJA, Boxma GL et al. Transmural myocardial infarction with sumatriptan. Lancet. 1993; 341:861-2. https://pubmed.ncbi.nlm.nih.gov/8096565

28. Hillis WS, Macintyre PD. Sumatriptan and chest pain. Lancet. 1993; 342:683. https://pubmed.ncbi.nlm.nih.gov/8103169

29. Hillis WS, MacIntyre PD. Sumatriptan and chest pain. Lancet. 1993; 341:1564-5. https://pubmed.ncbi.nlm.nih.gov/8099643

30. Ottervanger JP, Stricker BHC. Sumatriptan and chest pain. Lancet. 1993; 342:176.

31. Chester AH, O’Neil GS, Yacoub MH. Sumatriptan and ischaemic heart disease. Lancet. 1993; 341:1419-20. https://pubmed.ncbi.nlm.nih.gov/8098831

32. Bax WA, Saxena PR. Sumatriptan and ischaemic heart disease. Lancet. 1993; 341:1420. https://pubmed.ncbi.nlm.nih.gov/8098832

33. Myerburg RJ, Kessler KM, Mallon SM et al. Life-threatening ventricular arrhythmias in patients with silent myocardial ischemia due to coronary artery spasm. N Engl J Med. 1992; 326:1451-5. https://pubmed.ncbi.nlm.nih.gov/1574091

34. MacLean MR, Smith GCS, Templeton AGB. Adverse reactions associated with sumatriptan. Lancet. 1993; 341:1092.

35. Lloyd DK, Simmons V. Adverse reactions associated with sumatriptan. Lancet. 1993; 341:1092. https://pubmed.ncbi.nlm.nih.gov/8096981

36. Cavazos JE, Caress JB, Chilukuri VR et al. Sumatriptan-induced stroke in sagittal sinus thrombosis. Lancet. 1994; 343:1105-6. https://pubmed.ncbi.nlm.nih.gov/7909130

37. Cerenex Pharmaceuticals, Div. of Glaxo, Inc., Research Triangle Park, NC: Personal communication.

38. Humphrey PPA, Feniuk W. Mode of action of the anti-migraine drug sumatriptan. Trends Pharmacol Sci. 1991; 12:444-6. https://pubmed.ncbi.nlm.nih.gov/1665260

39. Lovenberg TW, Erlander MG, Baron BM et al. Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci USA. 1993; 90:2184-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC46050/ https://pubmed.ncbi.nlm.nih.gov/8384716

40. Cerenex Pharmaceuticals, Div. of Glaxo, Inc., Research Triangle Park, NC: Personal communication.

41. Sullivan JT, Preston KL, Testa MP et al. Psychoactivity and abuse potential of sumatriptan. Clin Pharmacol Ther. 1992; 52:635-42. https://pubmed.ncbi.nlm.nih.gov/1333934

42. Luman W, Gray RS. Adverse reactions associated with sumatriptan. Lancet. 1993; 341:1091-2. https://pubmed.ncbi.nlm.nih.gov/8096980

43. Caekebeke JFV, Ferrari MD, Zwetsloot CP et al. Antimigraine drug sumatriptan increases blood flow velocity in large cerebral arteries during migraine attacks. Neurology. 1992; 42:1522-6. https://pubmed.ncbi.nlm.nih.gov/1322512

44. Lacey LF, Fowler PA. The clinical pharmacology of sumatriptan. Cephalalgia. 1993; 13(Suppl 13):156.

45. Fowler PA, Lacey LF, Thomas M et al. The clinical pharmacology, pharmacokinetics, and metabolism of sumatriptan. Eur Neurol. 1991; 31:291-4. https://pubmed.ncbi.nlm.nih.gov/1653135

46. Dahlof C. Headache recurrence after subcutaneous sumatriptan and early treatment. Lancet. 1992; 340:909. https://pubmed.ncbi.nlm.nih.gov/1357313

47. Ferrari MD, Saxena PR. Clinical and experimental effects of sumatriptan in humans. Trends Pharmacol Sci. 1993; 14:129-33. https://pubmed.ncbi.nlm.nih.gov/8390743

48. Anon. Sumatriptan: a new approach to migraine. Drug Ther Bull. 1992; 30:85-7. https://pubmed.ncbi.nlm.nih.gov/1330474

49. The Sumatriptan Cluster Headache Study Group. Treatment of acute cluster headache with sumatriptan. N Engl J Med. 1991; 325:322-6. https://pubmed.ncbi.nlm.nih.gov/1647496

50. Lloyd DK, Pilgrim AJ. Sumatriptan and recurrence of migraine. Lancet. 1992; 340:1110. https://pubmed.ncbi.nlm.nih.gov/1357515

51. Blau JN. Sumatriptan and recurrence of migraine. Lancet. 1992; 340:1110. https://pubmed.ncbi.nlm.nih.gov/1357514

52. Black P, Caldwell J. Skin sensitivity to sumatriptan. N Z Med J. 1994; 107:20- 1. https://pubmed.ncbi.nlm.nih.gov/8295755

53. Sykes RS, Castle W, Palmer J. Sumatriptan-induced stroke in sagittal sinus thrombosis. Lancet. 1994; 343:1299-300. https://pubmed.ncbi.nlm.nih.gov/7910310

54. Carp H, Singh PJ, Vadhera R et al. Effects of the serotonin-receptor agonist sumatriptan on postdural puncture headache: report of six cases. Anesth Analg. 1994; 79:180-2. https://pubmed.ncbi.nlm.nih.gov/8010433

55. Solbach MP, Waymer RS. Treatment of menstruation-associated migraine headache with subcutaneous sumatriptan. Obstet Gynecol. 1993; 82:769-72. https://pubmed.ncbi.nlm.nih.gov/8414324

56. Cady RK, Dexter J, Sargent JD et al. Efficacy of subcutaneous sumatriptan in repeated episodes of migraine. Neurology. 1993; 43:1363-8. https://pubmed.ncbi.nlm.nih.gov/8392150

57. Thomson AN, Arthur GP, Bergin PS et al. Subcutaneous sumatriptan in acute treatment of migraine: a multicentre New Zealand trial. N Z Med J. 1993; 106:171-3. https://pubmed.ncbi.nlm.nih.gov/8389026

58. Bousser MG, d’Allens H, Richard A et al. Efficacy of subcutaneous sumatriptan in the acute treatment of early-morning migraine: a placebo-controlled trial. J Int Med. 1993; 234:211-6.

59. Goadsby PJ, Zagami AS, Donnan GA et al. Oral sumatriptan in acute migraine. Lancet. 1991; 338:782-3. https://pubmed.ncbi.nlm.nih.gov/1681162

60. Tfelt-Hansen P, Sperling B, Winter PDO’B. Transient additional effect of sumatriptan on ergotamine-induced constriction of peripheral arteries in man. Clin Pharmacol Ther. 1992; 51:149.

61. Posner JB. Disorders of sensation: headache and other pain. In: Wyngaarden JB, Smith LH Jr, Bennett JC, eds. Cecil textbook of medicine. 19th ed. Philadelphia: WB Saunders Company; 1992:2116-24.

62. Scott AK, Walley T, Breckenridge AM et al. Lack of an interaction between propranolol and sumatriptan. Br J Clin Pharmacol. 1991; 32:581-4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1368634/ https://pubmed.ncbi.nlm.nih.gov/1659437

63. Kaube H, May A, Diener HC et al. Sumatriptan. BMJ. 1994; 308:1573-4.

64. Osborne MJ, Austin RCT, Dawson KJ et al. Is there a problem with long term use of sumatriptan in acute migraine? Br Med J. 1994; 308:113. (IDIS 325298)

65. den Boer MO, Somers JAE, Saxena PR. Lack of effect of the antimigraine drugs, sumatriptan, ergotamine and dihydroergotamine on arteriovenous anastomotic shunting in the dura mater of the pig. Br J Pharmacol. 1992; 107:577-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907860/ https://pubmed.ncbi.nlm.nih.gov/1330188

66. Feniuk W, Humphrey PPA, Perren MJ. The selective carotid arterial vasoconstrictor action of GR43175 in anaesthetized dogs. Br J Pharmacol. 1989; 96:83-90. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854323/ https://pubmed.ncbi.nlm.nih.gov/2538184

67. Kaube H, Hoskin KL, Goadsby PJ. Inhibition by sumatriptan of central trigeminal neurones only after blood-brain barrier disruption. Br J Pharmacol. 1993; 109:788-92. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175651/ https://pubmed.ncbi.nlm.nih.gov/8395298

68. den Boer MO, Villalón CM, Heiligers JPC et al. Role of 5-HT1-like receptors in the reduction of porcine cranial arteriovenous anastomotic shunting by sumatriptan. Br J Pharmacol. 1991; 102:323-30. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1918020/ https://pubmed.ncbi.nlm.nih.gov/1849764

69. Bax WA, Renzenbrink GJ, Van Heuven-Nolsen D et al. 5-HT receptors mediating contractions of the isolated human coronary artery. Eur J Pharmacol. 1993; 239:203-10. https://pubmed.ncbi.nlm.nih.gov/7693489

70. Perren MJ, Feniuk W, Humphrey PPA. The selective closure of feline carotid arteriovenous anastomoses (AVAs) by GR43175. Cephalalgia. 1989; 9(Suppl 9):41-6. https://pubmed.ncbi.nlm.nih.gov/2544282

71. Goadsby PJ, Edvinsson L. The trigeminovascular system and migraine: studies characterizing cerebrovascular and neuropeptide changes seen in humans and cats. Ann Neurol. 1993; 33:48-56. https://pubmed.ncbi.nlm.nih.gov/8388188

72. Mathew NT, Dexter J, Couch J et al. Dose ranging efficacy and safety of subcutaneous sumatriptan in the acute treatment of migraine. Arch Neurol. 1992; 49:1271-6. https://pubmed.ncbi.nlm.nih.gov/1333181

73. Jansen I, Olesen J, Edvinsson L. 5-Hydroxytryptamine receptor characterization of human cerebral, middle meningeal and temporal arteries: regional differences. Acta Physiol Scand. 1993; 147:141-50. https://pubmed.ncbi.nlm.nih.gov/8386424

74. Nozaki K, Moskowitz MA, Boccalini P. CP-93,129, sumatriptan, dihydroergotamine block c-fos expression within rat trigeminal nucleus caudalis caused by chemical stimulation of the meninges. Br J Pharmacol. 1992; 106:409-15. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907519/ https://pubmed.ncbi.nlm.nih.gov/1327382

75. Ekbom K, Monstad I, Prusinski A et al. Subcutaneous sumatriptan in the acute treatment of cluster headache: a dose comparison study. Acta Neurol Scand. 1993; 88:63-9. https://pubmed.ncbi.nlm.nih.gov/8396833

76. Houghton LA, Fowler P, Keene ON et al. Effect of sumatriptan, a new selective 5HT1-like agonist, on liquid gastric emptying in man. Aliment Pharmacol Ther. 1992; 6:685-91. https://pubmed.ncbi.nlm.nih.gov/1336675

77. Humphrey PPA, Feniuk W, Perren MJ et al. The pharmacology of the novel 5- HT1-like receptor agonist, GR43175. Cephalalgia. 1989; 9(Suppl 9):23-33. https://pubmed.ncbi.nlm.nih.gov/2544280

78. Gutterman DL, Plachetka JR, Donn K et al. Evaluation of the safety and pharmacokinetic properties of single subcutaneous doses of GR43175C in healthy, adult, male volunteers. Cephalalgia. 1989; 9(Suppl 10):412-3.

79. Busch MA, Plachetka JR, Donn KH. Evaluation of the pharmacokinetics and safety of ascending single oral doses of GR43175 administered to healthy male volunteers. Cephalalgia. 1989; 9(Suppl 10):414-5.

80. Italian Society for the Study of Headache. Guidelines and recommendations for the treatment of migraine. Funct Neurol. 1993; 8:441-6. https://pubmed.ncbi.nlm.nih.gov/8150324

81. Muly EC, McDonald W, Steffens D et al. Serotonin syndrome produced by a combination of fluoxetine and lithium. Am J Psychiatry. 1993; 150:1565. https://pubmed.ncbi.nlm.nih.gov/8379573

82. Tansey MJB, Pilgrim AJ, Martin PM. Long-term experience with sumatriptan in the treatment of migraine. Eur Neurol. 1993; 33:310-5. https://pubmed.ncbi.nlm.nih.gov/8394239

83. Peroutka SJ, McCarthy BG. Sumatriptan (GR43175) interacts selectively with 5- HT1B and 5-HT1D binding sites. Eur J Pharmacol. 1989; 163:133-6. https://pubmed.ncbi.nlm.nih.gov/2545459

84. The Oral Sumatriptan and Aspirin plus Metoclopramide Comparative Study Group. A study to compare oral sumatriptan with oral aspirin plus oral metoclopramide in the acute treatment of migraine. Eur Neurol. 1992; 32:177-84. https://pubmed.ncbi.nlm.nih.gov/1317294

85. Chester AH, Martin GR, Bodelsson M et al. 5-Hydroxytryptamine receptor profile in healthy and diseased human epicardial coronary arteries. Cardiovasc Res. 1990; 24:932-7. https://pubmed.ncbi.nlm.nih.gov/2272071

86. Sumner MJ, Humphrey PPA. Sumatriptan (GR43175) inhibits cyclic-AMP accumulation in dog isolated saphenous vein. Br J Pharmacol. 1990; 99:219-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1917383/ https://pubmed.ncbi.nlm.nih.gov/2158369

87. Humphrey PPA, Feniuk W, Perren MJ et al. Serotonin and migraine. Ann NY Acad Sci. 1990; 600:587-98. https://pubmed.ncbi.nlm.nih.gov/2252337

88. Parsons AA, Whalley ET. Characterization of the 5-hydroxytryptamine receptor which mediates contraction of the human isolated basilar artery. Cephalalgia. 1989; 9(Suppl 9):47-51. https://pubmed.ncbi.nlm.nih.gov/2544283

89. Fowler PA, Thomas M, Lacey LF et al. Early studies with the novel 5-HT1-like agonist GR43175 in healthy volunteers. Cephalalgia. 1989; 9(Suppl 9):57-62. https://pubmed.ncbi.nlm.nih.gov/2544285

90. Perrin VL, Färkkilä M, Goasguen J et al. Overview of initial clinical studies with intravenous and oral GR43175 in acute migraine. Cephalalgia. 1989; 9(Suppl 9):63- 72. https://pubmed.ncbi.nlm.nih.gov/2544286

91. Tfelt-Hansen P, Brand J, Dano P et al. Early clinical experience with subcutaneous GR43175 in acute migraine: an overview. Cephalalgia. 1989; 9(Suppl 9):73-7. https://pubmed.ncbi.nlm.nih.gov/2544287

92. The Oral Sumatriptan International Multiple-Dose Study Group. Evaluation of a multiple-dose regimen of oral sumatriptan for the acute treatment of migraine. Eur Neurol. 1991; 31:306-13. https://pubmed.ncbi.nlm.nih.gov/1653138

93. The Sumatriptan Auto-Injector Study Group. Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device. Eur Neurol. 1991; 31:323-31. https://pubmed.ncbi.nlm.nih.gov/1653140

94. Brown EG, Endersby CA, Smith RN et al. The safety and tolerability of sumatriptan: an overview. Eur Neurol. 1991; 31:339-44. https://pubmed.ncbi.nlm.nih.gov/1653142

95. Moskowitz MA, Macfarlane R. Neurovascular and molecular mechanisms in migraine headaches. Cerebrovasc Brain Metab Rev. 1993; 5:159-77. https://pubmed.ncbi.nlm.nih.gov/8217498

96. Cutler NR, Hussey EK, Sramek JJ et al. Pharmacokinetics (PK) of oral sumatriptan in migraine patients during an attack and while painfree. Biol Psych. 1992; 31:180A.

97. Facchinetti F, Nappi RE, Sances G et al. The neuroendocrine effects of sumatriptan, a specific ligand for 5-HT1-like receptors. Clin Endocrinol. 1994; 40:211-4.

98. McCarthy BG, Peroutka SJ. Comparative neuropharmacology of dihydroergotamine and sumatriptan (GR43175). Headache. 1989; 29:420-2. https://pubmed.ncbi.nlm.nih.gov/2547733

99. Galer BS, Lipton RB, Solomon S et al. Myocardial ischemia related to ergot alkaloids: a case report and literature review. Headache. 1991; 31:446-50. https://pubmed.ncbi.nlm.nih.gov/1774159

100. Panconesi A, Anselmi B, Curradi C et al. Comparison between venoconstrictor effects of sumatriptan and ergotamine in migraine patients. Headache. 1994; 34:194-7. https://pubmed.ncbi.nlm.nih.gov/8014033

101. Peroutka SJ, Havlik S, Oksenberg D. Wolff award presentation 1993. Anti-migraine drug interactions with cloned human 5-hydroxytryptaminel receptor subtypes. Headache. 1993; 33:347-50. https://pubmed.ncbi.nlm.nih.gov/8397171

102. Connor HE, Feniuk W, Humphrey PPA. 5-Hydroxytryptamine contracts human coronary arteries predominantly via 5-HT2 receptor activation. Eur J Pharmacol. 1989; 161:91-4. https://pubmed.ncbi.nlm.nih.gov/2542039

103. Goadsby PJ, Edvinsson L. Human in vivo evidence for trigeminovascular activation in cluster headache: neuropeptide changes and effects of acute attacks therapies. Brain. 1994; 117:427-34. https://pubmed.ncbi.nlm.nih.gov/7518321

104. Dixon CM, Park GR, Tarbit MH. Characterization of the enzyme responsible for the metabolism of sumatriptan in human liver. Biochem Pharmacol. 1994; 47:1253-7. https://pubmed.ncbi.nlm.nih.gov/8161354

105. Humphrey PPA, Feniuk W, Perren MJ et al. GR43175, a selective agonist for the 5- HT1-like receptor in dog isolated saphenous vein. Br J Pharmacol. 1988; 94:1123- 32. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1854075/ https://pubmed.ncbi.nlm.nih.gov/2850055

106. Rebeck GW, Maynard KI, Hyman BT et al. Selective 5-HT1D α serotonin receptor gene expression in trigeminal ganglia: implications for antimigraine drug development. Proc Natl Acad Sci USA. 1994; 91:3666-9. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC43642/ https://pubmed.ncbi.nlm.nih.gov/8170966

107. Totaro R, De Matteis G, Marini C et al. Effect of sumatriptan on cerebral blood flow velocity measured by transcranial doppler. Stroke. 1993; 24:516.

108. Nappi G, Sicuteri F, Byrne M et al. Oral sumatriptan compared with placebo in the acute treatment of migraine. J Neurol. 1994; 241:138-44. https://pubmed.ncbi.nlm.nih.gov/8164015

109. Ebersole BJ, Diglio CA, Kaufman DW et al. 5-Hydroxytryptamine1-like receptors linked to increases in intracellular calcium concentration and inhibition of cyclic AMP accumulation in cultured vascular smooth muscle cells derived from bovine basilar artery. J Pharmacol Exp Ther. 1993; 266:692-9. https://pubmed.ncbi.nlm.nih.gov/8394913

110. Den Boer MO, Villalón CM, Saxena PR. 5-HT1-like receptor mediated changes in porcine carotid haemodynamics: are 5-HT1D receptors involved? Arch Pharmacol. 1992; 345:509-15.

111. Ensink FBM for the Sumatriptan International Study Group. Subcutaneous sumatriptan in the acute treatment of migraine. J Neurol. 1991; 238(Suppl 1):S66-9.

112. Wayne VS. A possible relationship between migraine and coronary artery spasm. Aust N Z J Med. 1986; 16:708-10. https://pubmed.ncbi.nlm.nih.gov/3469972

113. Saper JR. Ergotamine dependency: a review. Headache. 1987; 27:435-8. https://pubmed.ncbi.nlm.nih.gov/3117735

114. Lloyd DK, Arnold WSG. Long term use of sumatriptan. BMJ. 1994; 308:533.

115. Miller D, Waters DD, Warnica W et al. Is variant angina the coronary manifestation of a generalized vasospastic disorder? N Engl J Med. 1981; 304:763-6.

116. Leviton A, Malvea B, Graham JR. Vascular diseases, mortality, and migraine in the parents of migraine patients. Neurology. 1974; 24:669-72. https://pubmed.ncbi.nlm.nih.gov/4858091

117. Moskowitz MA, Buzzi MG. Neuroeffector functions of sensory fibres: implications for headache mechanisms and drug actions. J Neurol. 1991; 238(Suppl 1):S18-22. https://pubmed.ncbi.nlm.nih.gov/2045826

118. Saxena PR, Den Boer MO. Pharmacology of antimigraine drugs. J Neurol. 1991; 238(Suppl 1):S28-35. https://pubmed.ncbi.nlm.nih.gov/1646288

119. Feniuk W, Humphrey PPA, Perren MJ et al. Rationale for the use of 5-HT1- like agonists in the treatment of migraine. J Neurol. 1991; 238(Suppl 1):S57-61. https://pubmed.ncbi.nlm.nih.gov/1646289

120. Bax WA, Van Heuven-Nolsen D, Bos E et al. 5-hydroxytryptamine-induced contractions of the human isolated saphenous vein: involvement of 5-HT2 and 5- HT1D-like receptors, and a comparison with grafted veins. Arch Pharmacol. 1992; 345:500-8.

121. Buzzi MG, Carter WB, Shimizu T et al. Dihydroergotamine and sumatriptan attenuate levels of CGRP in plasma in rat superior sagittal sinus during electrical stimulation of the trigeminal ganglion. Neuropharmacology. 1991; 30:1193-200. https://pubmed.ncbi.nlm.nih.gov/1663596

122. Franceschini R, Cataldi A, Garibaldi A et al. The effects of sumatriptan on pituitary secretion in man. Neuropharmacology. 1994; 33:235-9. https://pubmed.ncbi.nlm.nih.gov/8035909

123. The Finnish Sumatriptan Group and the Cardiovascular Clinical Research Group. A placebo-controlled study of intranasal sumatriptan for the acute treatment of migraine. Eur Neurol. 1991; 31:332-8. https://pubmed.ncbi.nlm.nih.gov/1653141

124. The Multinational Oral Sumatriptan and Cafergot Comparative Study Group. A randomized, double-blind comparison of sumatriptan and cafergot in the acute treatment of migraine. Eur Neurol. 1991; 31:314-22. https://pubmed.ncbi.nlm.nih.gov/1653139

125. Buzzi MG, Dimitriadou V, Theoharides TC et al. 5-Hydroxytryptamine receptor agonists for the abortive treatment of vascular headaches block mast cell, endothelial and platelet activation within the rat dura mater after trigeminal stimulation. Brain Res. 1992; 583:137-49. https://pubmed.ncbi.nlm.nih.gov/1324091

126. Bruinvels AT, Lery H, Nozulak J et al. 5-HT1D binding sites in various species: similar pharmacological profile in dog, monkey, calf, guinea-pig and human brain membranes. Arch Pharmacol. 1992; 346:243-8.

127. De Keyser J, Vauquelin G, De Backer JP et al. What intracranial tissues in humans contain sumatriptan-sensitive serotonin 5-HT1-type receptors? Neurosci Lett. 1993; 164:63-6.

128. Waeber C, Hoyer D, Palacios JM. GR43175: a preferential 5-HT1D agent in monkey and human brains as shown by autoradiography. Synapse. 1989; 4:168-70. https://pubmed.ncbi.nlm.nih.gov/2551055

129. Bruinvels AT, Landwehrmeyer B, Probst A et al. A comparative autoradiographic study of 5-HT1D binding sites in human and guinea-pig brain using different radioligands. Molecul Brain Res. 1994; 21:19-29.

130. Cocks TM, Kemp BK, Pruneau D et al. Comparison of contractile responses to 5- hydroxytryptamine and sumatriptan in human isolated coronary artery: synergy with the thromboxane A2-receptor agonist, U46619. Br J Pharmacol. 1993; 110:360-8. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2176043/ https://pubmed.ncbi.nlm.nih.gov/8220898

131. Edvinsson L, Jansen I, Olesen J. Characterization of human craniovascular 5- hydroxytryptamine receptors. Front Headache Res. 1992; 2:129-36.

132. Beer MS, Stanton JA, Bevan Y et al. L-694,247: a potent 5-HT1D receptor agonist. Br J Pharmacol. 1993; 110:1196-200. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2175804/ https://pubmed.ncbi.nlm.nih.gov/8298808

133. Huang Z, Byun B, Matsubara T et al. Time-dependent blockade of neurogenic plasma extravasation in dura mater by 5-HT1B/D agonists and endopeptidase 24.11. Br J Pharmacol. 1993; 108:331-5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1907980/ https://pubmed.ncbi.nlm.nih.gov/8383561

134. Brennum J, Kjeldsen M, Olesen J. The 5-HT1-like agonist sumatriptan has a significant effect in chronic tension-type headache. Cephalalgia. 1992; 12:375-9. https://pubmed.ncbi.nlm.nih.gov/1335361

135. Hamblin MW, Metcalf MA, McGuffin RW et al. Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5- HT1B receptor with 5-HT1D-like pharmacological specificity. Biochem Biophys Res Comm. 1992; 184:752-9. https://pubmed.ncbi.nlm.nih.gov/1315531

136. Sleight AJ, Cervenka A, Peroutka SJ. In vivo effects of sumatriptan (GR 43175) on extracellular levels of 5-HT in the guinea pig. Neuropharmacology. 1990; 29:511-3. https://pubmed.ncbi.nlm.nih.gov/2166920

137. Adham N, Kao HT, Schechter LE et al. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc Natl Acad Sci USA. 1993; 90:408-12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC45671/ https://pubmed.ncbi.nlm.nih.gov/8380639

138. Connor HE, Stubbs CM, Feniuk W et al. Effect of sumatriptan, a selective 5- HT1-like receptor agonist, on pial vessel diameter in anaesthetised cats. J Cerebral Blood Flow Metabol. 1992; 12:514-9.

139. Maura G, Thellung S, Andrioli GC et al. Release-regulating serotonin 5-HT1D autoreceptors in human cerebral cortex. J Neurochem. 1993; 60:1179-82. https://pubmed.ncbi.nlm.nih.gov/8382263

140. Diener HC, Haab J, Peters C et al. Subcutaneous sumatriptan in the treatment of headache during withdrawal from drug-induced headache. Headache. 1991; 31:205-9. https://pubmed.ncbi.nlm.nih.gov/1646775

141. Mills KC. Serotonin syndrome. Am Fam Physician. 1995; 52:1474-82.

142. Henry P, d’Allens H, French Migraine Network Bordeaux-Lyon-Grenoble. Subcutaneous sumatriptan in the acute treatment of migraine in patients using dihydroergotamine as prophylaxis. Headache. 1993; 33:432-5. https://pubmed.ncbi.nlm.nih.gov/8262783

143. Schoenen J, Bulcke J, Caekebeke J et al. Self-treatment of acute migraine with subcutaneous sumatriptan using an auto-injector device: comparison with customary treatment in an open, longitudinal study. Cephalalgia. 1994; 14:55-63. https://pubmed.ncbi.nlm.nih.gov/8200027

144. Lloyd DK, Pilgrim AJ. The safety of sumatriptan in asthmatic migraineurs. Cephalalgia. 1993; 13:201-4. https://pubmed.ncbi.nlm.nih.gov/8395345

145. Banerjee M, Findley LJ. Sumatriptan in the treatment of acute migraine with aura. Cephalalgia. 1992; 12:39-44. https://pubmed.ncbi.nlm.nih.gov/1313746

146. Scott AK. Sumatriptan: clinical pharmacokinetics. Clin Pharmacokinet. 1994; 27:337-44. https://pubmed.ncbi.nlm.nih.gov/7851052

147. Bärtsch P, Maggi S, Kleger GR et al. Sumatriptan for high altitude headache. Lancet. 1994; 344:1445. https://pubmed.ncbi.nlm.nih.gov/7968111

148. GlaxoSmithKline. Imitrex (sumatriptan succinate) tablets prescribing information. Research Triangle Park, NC; 2012 Mar.

149. Chiari M, Manzoni GC, van de Geijn EJ. Ischemic optic neuropathy after sumatriptan in a migraine with aura patient. Headache. 1994; 34:237-8. https://pubmed.ncbi.nlm.nih.gov/8014044

150. Palmer J, Feldman R, Mancini GB et al. Glyceryl trinitrate reversal of post- sumatriptan coronary artery narrowing. Lancet. 1995; 345:1366. https://pubmed.ncbi.nlm.nih.gov/7752771

151. Szabo CP. Fluoxetine and sumatriptan: possibly a counterproductive combination. J Clin Psychiatry. 1995; 56:37-8. https://pubmed.ncbi.nlm.nih.gov/7836342

152. Jayamaha JEL, Street MK. Fatal cerebellar infarction in a migraine sufferer whilst receiving sumatriptan. Intensive Care Med. 1995; 21:82-3. https://pubmed.ncbi.nlm.nih.gov/7560482

153. La Porta LD. Recurrent depression after sumatriptan administration for treatment of migraine. J Clin Psychopharmacol. 1995; 15:81-2. https://pubmed.ncbi.nlm.nih.gov/7714232

154. Anon. Sumatriptan: rebound headache and migraine exacerbation. CMAJ. 1995; 152:66.

155. Evers S, Husstedt IW, Enbergs A. Coronary angiography in migraine patient after subcutaneous sumatriptan. Lancet. 1995; 345:198. https://pubmed.ncbi.nlm.nih.gov/7823698

156. Garcia G, Kaufman MB, Colucci RD. Dystonic reaction associated with sumatriptan. Ann Pharmacother. 1994; 28:1199. https://pubmed.ncbi.nlm.nih.gov/7841582

157. Shane R. Development and implementation of practice guidelines (part 1). Hosp Formul. 1994; 29:711-9. https://pubmed.ncbi.nlm.nih.gov/10137848

158. Bates D, Ashford E, Dawson R et al. Subcutaneous sumatriptan during the migraine aura. Neurology. 1994; 44:1587-92. https://pubmed.ncbi.nlm.nih.gov/7936279

159. Houghton LA, Foster JM, Whorwell PJ et al. Is chest pain after sumatriptan oesophageal in origin? Lancet. 1994; 344:985-6.

160. Hood S, Birnie D, MacIntyre PD et al. Sumatriptan-induced chest pain. Lancet. 1994; 344:1500-1. https://pubmed.ncbi.nlm.nih.gov/7832891

161. Entwisle SJ, Fowler PA, Thomas M et al. The effects of oral sumatriptan, a 5- HT1 receptor agonist, on circulating ACTH and cortisol concentrations in man. Br J Clin Pharmacol. 1995; 39:389-95. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1365126/ https://pubmed.ncbi.nlm.nih.gov/7640145

162. Akpunonu BE, Mutgi AB, Federman DJ et al. Subcutaneous sumatriptan for treatment of acute migraine in patients admitted to the emergency department: a multicenter study. Ann Emerg Med. 1995; 25:464-9. https://pubmed.ncbi.nlm.nih.gov/7710149

163. Boyd IW, Rohan AP. Sumatriptan-induced chest pain. Lancet. 1994; 344:1704-5. https://pubmed.ncbi.nlm.nih.gov/7996981

164. Bhanji NH. Sumatriptan and chest pain. Can J Hosp Pharm. 1994; 47:232-4.

165. Gaist D, Sindrup S, Hallas J et al. Misuse of sumatriptan. Lancet. 1994; 344:1090. https://pubmed.ncbi.nlm.nih.gov/7934471

166. Warner PE, Brouwer KLR, Hussey EK et al. Sumatriptan absorption from different regions of the human gastrointestinal tract. Pharm Res. 1995; 12:138-43. https://pubmed.ncbi.nlm.nih.gov/7724476

167. Anon. Drugs for migraine. Med Lett Drugs Ther. 1995; 37:17-20. https://pubmed.ncbi.nlm.nih.gov/7862023

168. Lacey LF, Hussey EK, Fowler PA. Single dose pharmacokinetics of sumatriptan in healthy volunteers. Eur J Clin Pharmacol. 1995; 47:543-8. https://pubmed.ncbi.nlm.nih.gov/7768259

169. Ferrari MD, Haan J, Blokland AK et al. Cerebral blood flow during migraine attacks without aura and effect of sumatriptan. Arch Neurol. 1995; 52:135-9. https://pubmed.ncbi.nlm.nih.gov/7848120

170. Pini LA, Trenti T. Does chronic use of sumatriptan induce dependence? Headache. 1994; 34:600.

171. Gross MLP, Kay J, Turner AM et al. Sumatriptan in acute migraine using a novel cartridge system self-injector. Headache. 1994; 34:559-63. https://pubmed.ncbi.nlm.nih.gov/7843948

172. Catarci T, Fiacco F, Argentino C et al. Ergotamine-induced headache can be sustained by sumatriptan daily intake. Cephalalgia. 1994; 14:374-5. https://pubmed.ncbi.nlm.nih.gov/7828198

173. Ferrari MD, James MH, Bates D et al. Oral sumatriptan: effect of a second dose, and incidence and treatment of headache recurrences. Cephalalgia. 1994; 14:330-8. https://pubmed.ncbi.nlm.nih.gov/7828190

174. Russell MB, Holm-Thomsen OE, Nielsen MR et al. A randomized double-blind placebo-controlled crossover study of subcutaneous sumatriptan in general practice. Cephalalgia. 1994; 14:291-6. https://pubmed.ncbi.nlm.nih.gov/7954759

175. Doenicke A, Melchart D, Bayliss EM. Effective improvement of symptoms in patients with acute migraine by GR43175 administered in dispersible tablets. Cephalalgia. 1989; 9(Suppl 9):89-92. https://pubmed.ncbi.nlm.nih.gov/2544290

176. Ferrari MD, Saxena PRS. Clinical effects and mechanism of action of sumatriptan in migraine. Clin Neurol Neurosurg. 1992; 94(Suppl):S73-7.

177. Hoyer D, Clarke DE, Fozard JR et al. International union of pharmacology classification of receptors for 5-hydroxytryptamine (serotonin). Pharmacol Rev. 1994; 46:157-203. https://pubmed.ncbi.nlm.nih.gov/7938165

178. Tansey MJB, Pilgrim AJ, Lloyd K. Sumatriptan in the acute treatment of migraine. J Neurol Sci. 1993; 114:109-16. https://pubmed.ncbi.nlm.nih.gov/8381852

179. MacDonald JT. Treatment of juvenile migraine with subcutaneous sumatriptan. Headache. 1994; 34:581-2. https://pubmed.ncbi.nlm.nih.gov/7843952

180. The Oral Sumatriptan Dose-Defining Study Group. Sumatriptan—an oral dose- defining study. Eur Neurol. 1991; 31:300-5. https://pubmed.ncbi.nlm.nih.gov/1653137

181. Cady RK, Rubino J, Crummett D et al. Oral sumatriptan in the treatment of recurrent headache. Arch Fam Med. 1994; 3:766-72. https://pubmed.ncbi.nlm.nih.gov/7987510

182. Suchowersky O. Rebound headaches due to sumatriptan. Neurology. 1993; 43(Suppl 2):A326. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429957/

183. Ekbom K, Krabbe A, Micelli G et al et al. Cluster headache attacks treated for up to three months with subcutaneous sumatriptan (6 mg). Cephalalgia. 1995; 15:230-6. https://pubmed.ncbi.nlm.nih.gov/7553814

184. Hardebo JE. Subcutaneous sumatriptan in cluster headache: a time study of the effect on pain and autonomic symptoms. Headache. 1993; 33:18-21. https://pubmed.ncbi.nlm.nih.gov/8382200

185. Monstad I, Krabbe A, Micieli G et al. Preemptive oral treatment with sumatriptan during a cluster period. Headache. 1995; 35:607-13. https://pubmed.ncbi.nlm.nih.gov/8550362

186. Fanciullacci M, Alessandri M, Figini M et al. Increase in plasma calcitonin gene- related peptide from the extracerebral circulation during nitroglycerin-induced cluster headache attack. Pain. 1995; 60:119-23. https://pubmed.ncbi.nlm.nih.gov/7540279

187. Rani PU, Naidu MUR, Rao TRK et al. Sumatriptan delays paracetamol absorption in migraine patients. Clin Drug Invest. 1996; 11:300-4.

188. Drummond PD, Lance JW. Thermographic changes in cluster headache. Neurology. 1984; 34:1292-8. https://pubmed.ncbi.nlm.nih.gov/6541301

189. Rapoport AM, Visser WH, Cutler NR et al. Oral sumatriptan in preventing headache recurrence after treatment of migraine attacks with subcutaneous sumatriptan. Neurology. 1995; 45:1505-9. https://pubmed.ncbi.nlm.nih.gov/7644049

190. Cutler N, Mushet GR, Davis R et al. Oral sumatriptan for the acute treatment of migraine: evaluation of three dosage strengths. Neurology. 1995; 45(Suppl 7):S5-9.

191. Rederich G, Rapoport A, Cutler N et al. Oral sumatriptan for the long-term treatment of migraine: clinical findings. Neurology. 1995; 45(Suppl 7):S15-20.

192. Blier P, Bergeron R. The safety of concomitant use of sumatriptan and antidepressant treatments. J Clin Psychopharmacol. 1995; 15:106-9. https://pubmed.ncbi.nlm.nih.gov/7782482

193. Diamond S. The use of sumatriptan in patients on monoamine oxidase inhibitors. Neurology. 1995; 45:1039-40. https://pubmed.ncbi.nlm.nih.gov/7783861

194. Kelly KM. Cardiac arrest following use of sumatriptan. Neurology. 1995; 45:1211-3. https://pubmed.ncbi.nlm.nih.gov/7783891

195. Goadsby PJ, Olesen J. Diagnosis and management of migraine. BMJ. 1996; 312:1279-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2351074/ https://pubmed.ncbi.nlm.nih.gov/8634619

196. Edvinsson L, Goadsby PJ. Neuropeptides in migraine and cluster headache. Cephalalgia. 1994; 14:320-7. https://pubmed.ncbi.nlm.nih.gov/7828188

197. Moskowitz MA. Neurogenic inflammation in the pathophysiology and treatment of migraine. Neurology. 1993; 43(Suppl 3):S16-20. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2429957/ https://pubmed.ncbi.nlm.nih.gov/8389008

198. Headache Classification Committee of the International Headache Society. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia. 1988; 8(Suppl 7):19-28.

199. Robbins L. Intranasal lidocaine for cluster headache. Headache. 1995; 35:83- 4. https://pubmed.ncbi.nlm.nih.gov/7737866

200. Kudrow L, Kudrow DB. Intranasal lidocaine. Headache. 1995; 35:565-6. https://pubmed.ncbi.nlm.nih.gov/8530286

201. Kittrelle JP, Grouse DS, Seybold ME. Cluster headache: local anesthetic abortive agents. Arch Neurol. 1985; 42:496-8. https://pubmed.ncbi.nlm.nih.gov/3994568

202. Ghose RR. SUNCT syndrome. Med J Aust. 1995; 162:667-8. https://pubmed.ncbi.nlm.nih.gov/7603383

203. Choi A, Laurito CE, Cunningham FE. Pharmacologic management of postdural puncture headache. Ann Pharmacother. 1996; 30:831-9. https://pubmed.ncbi.nlm.nih.gov/8826568

204. Burtscher M, Likar R, Nachbauer W et al. Ibuprofen versus sumatriptan for high- altitude headache. Lancet. 1995; 346:254-5. https://pubmed.ncbi.nlm.nih.gov/7616830

205. Mathew NT. Long-term subcutaneous sumatriptan in cluster headache. Cephalalgia. 1995; 15:164. https://pubmed.ncbi.nlm.nih.gov/7553802

206. Benson JM, Zorn SL, Book LS. Sumatriptan in the treatment of cyclic vomiting. Ann Pharmacother. 1995; 29:997-9. https://pubmed.ncbi.nlm.nih.gov/8845562

207. Maizels M, Scott B, Cohen W et al. Intranasal lidocaine for treatment of migraine. JAMA. 1996; 276:319-21. https://pubmed.ncbi.nlm.nih.gov/8656545

208. Kudrow L, Kudrow DB, Sandweiss JH. Rapid and sustained relief of migraine attacks with intranasal lidocaine: preliminary findings. Headache. 1995; 35:79-82. https://pubmed.ncbi.nlm.nih.gov/7737865

209. Ekbom K, Waldenlind E, Cole J et al. Sumatriptan in chronic cluster headache: results of continuous treatment for eleven months. Cephalalgia. 1992; 12:254-6. https://pubmed.ncbi.nlm.nih.gov/1326405

210. Stovner LJ, Sjaastad O. Treatment of headache and its variants. Curr Opin Neurol. 1995; 8:243-7. https://pubmed.ncbi.nlm.nih.gov/7551127

211. Stratton SJ. Sumatriptan: a clinical standard? Ann Emerg Med. 1995; 25:538- 9. Letter. (IDIS 345057)

212. Stratton SJ. Sumatriptan and migraine. Ann Emerg Med. 1996; 27:388. https://pubmed.ncbi.nlm.nih.gov/8599507

213. Akpunonu BE, Mutgi AB. Sumatriptan and migraine. Ann Emerg Med. 1996; 27:387-8. https://pubmed.ncbi.nlm.nih.gov/8599506

214. Dahlof C, Ekbom K, Persson L. Clinical experiences from Sweden on the use of subcutaneously administered sumatriptan in migraine and cluster headache. Arch Neurol. 1994; 51:1256-61. https://pubmed.ncbi.nlm.nih.gov/7986182

215. Anthony M, Hinterberger H, Lance JW. Plasma serotonin in migraine and stress. Arch Neurol. 1967; 16:544-52. https://pubmed.ncbi.nlm.nih.gov/5297855

216. Kimball RW, Friedman AP, Vallejo E. Effect of serotonin in migraine patients. Neurology. 1960; 10:107-11. https://pubmed.ncbi.nlm.nih.gov/14409092

217. Wilkinson M, Pfaffenrath V, Schoenen J et al. Migraine and cluster headache—their management with sumatriptan: a critical review of the current clinical experience. Cephalalgia. 1995; 15:337-57. https://pubmed.ncbi.nlm.nih.gov/8536293

218. Mueller L, Gallagher RM, Ciervo CA. Vasospasm-induced myocardial infarction with sumatriptan. Headache. 1996; 36:329-31. https://pubmed.ncbi.nlm.nih.gov/8682677

219. Shader RI. I read a recent report suggesting a causal relationship between a dystonic reaction in a patient and her use of sumatriptan. Is this likely? J Clin Psychopharmacol. 1995; 15:231. Commentary. (IDIS 347590)

220. Ottervanger JP, van Witsen TB, Valkenburg HA et al. Adverse reactions attributed to sumatriptan: a postmarketing study in general practice. Eur J Clin Pharmacol. 1994; 47:305-9. https://pubmed.ncbi.nlm.nih.gov/7875179

221. Dachs R, Vitillo J. Angioedema associated with sumatriptan administration. Am J Med. 1995; 99:684-5. https://pubmed.ncbi.nlm.nih.gov/7503094

222. Bakshi R, Yan-Go FL. Prolonged marijuana-like dysphoria after subcutaneous sumatriptan. Ann Pharmcother. 1996; 30:683.

223. Fuller RW. Mechanisms and functions of serotonin neuronal systems: opportunities for neuropeptide interactions. Ann NY Acad Sci. 1996; 780:176-84. https://pubmed.ncbi.nlm.nih.gov/8602731

224. Pierce PA, Xie GX, Peroutka SJ et al. Dual effect of the serotonin agonist, sumatriptan, on peripheral neurogenic inflammation. Reg Anesth. 1996; 21:219-25. https://pubmed.ncbi.nlm.nih.gov/8744664

225. Facchinetti F, Bonellie G, Kangasniemi P et al et al. The efficacy and safety of subcutaneous sumatriptan in the acute treatment of menstrual migraine. Obstet Gynecol. 1995; 86:911-6. https://pubmed.ncbi.nlm.nih.gov/7501338

226. Winner P, Ricalde O, Le Force B et al. A double-blind study of subcutaneous dihydroergotamine vs subcutaneous sumatriptan in the treatment of acute migraine. Arch Neurol. 1996; 53:180-4. https://pubmed.ncbi.nlm.nih.gov/8639069

227. Stallard N, Barry P. Another complication of the combined extradural-subarachnoid technique. Br J Anaesth. 1995; 75:370-1. https://pubmed.ncbi.nlm.nih.gov/7547064

228. Gawel MJ, Rothbart P, Jacobs H. Subcutaneous sumatriptan in the treatment of acute episodes of posttraumatic headache. Headache. 1993; 33:96-7. https://pubmed.ncbi.nlm.nih.gov/8384612

229. Dahlof C. Subcutaneous sumatriptan does not abort attacks of chronic paroxysmal hemicrania (CPH). Headache. 1993; 33:201-2. https://pubmed.ncbi.nlm.nih.gov/8388371

230. Hannerz J, Jogestrand T. Intracranial hypertension and sumatriptan efficacy in a case of chronic paroxysmal hemicrania which became bilateral. Headache. 1993; 33:320-3. https://pubmed.ncbi.nlm.nih.gov/8394301

231. Hannerz J, Greitz D, Hansson P et al. SUNCT may be another manifestation of orbital venous vasculitis. Headache. 1992; 32:384-9. https://pubmed.ncbi.nlm.nih.gov/1399559

232. Bonuccelli U, Nuti A, Lucetti C et al. Amitriptyline and dexamethasone combined treatment in drug-induced headache. Cephalalgia. 1996; 16:197-200.

233. Hannington-Kiff JG. Sumatriptan relieves and prevents peri-operative migraine attacks. Anaesthesia. 1993; 48:144-6. https://pubmed.ncbi.nlm.nih.gov/8384803

234. Wing Y-K, Clifford EM, Sheehan BD et al. Paroxetine treatment and the prolactin response to sumatriptan. Psychopharmacology. 1996; 124:377-9. https://pubmed.ncbi.nlm.nih.gov/8739554

235. Schenker S, Yang Y, Perez A et al. Sumatriptan (Imitrex) transport by the human placenta. (43941) Proc Soc Exp Biol Med. 1995; 210:213-20.

236. Glaxo Wellcome, Research Triangle Park, NC: Personal communication.

237. Reviewers’ comments (personal observations).

238. Nielsen TH, Tfelt-Hansen P. Lack of effect of GR43175 on peripheral arteries in man. Cephalalgia. 1989; 9(Suppl 9):93-5. https://pubmed.ncbi.nlm.nih.gov/2544291

239. Doenicke A, Brand J, Perrin VL. Possible benefit of GR43175, a novel 5-HT1-like receptor agonist, for the acute treatment of severe migraine. Lancet. 1988; 1:1309-11. https://pubmed.ncbi.nlm.nih.gov/2897560

240. Hoerlein M, McMonigle G, Franz DN. Sumatriptan therapy of pediatric migraines. Ann Neurol. 1994; 36:548.

241. Linder SL. Subcutaneous sumatriptan in the clinical setting: the first fifty consecutive patients with acute migraine in a pediatric neurology office practice. Headache. 1995; 35:292-3.

242. Wojnar-Horton RE, Hackett LP, Yapp P et al. Distribution and excretion of sumatriptan in human milk. Br J Clin Pharmacol. 1996; 41:217-21. https://pubmed.ncbi.nlm.nih.gov/8866921

243. Salonen R, Ashford E, Dahlöf C et al et al. Intranasal sumatriptan for the acute treatment of migraine. J Neurol. 1994; 241:463-9. https://pubmed.ncbi.nlm.nih.gov/7964913

244. Pryse-Phillips WEM, Dodick DW, Edmeads JG et al. Guidelines for the diagnosis and management of migraine in clinical practice. CMAJ. 1997; 156:1273-87. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1227329/ https://pubmed.ncbi.nlm.nih.gov/9145054

245. Danish Neurological Society and the Danish Headache Society. Guidelines for the management of headache. Cephalalgia. 1998; 18:9-22. https://pubmed.ncbi.nlm.nih.gov/9601619

246. Peroutka SJ. Drugs effective in the therapy of migraine. In: Hardman JG, Limbird LE, Molinoff PB et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 9th ed. New York: McGraw-Hill; 1995:487-502.

247. Young WB, Silberstein SD, Dayno JM. Migraine treatment. Semin Neurol. 1997; 17:325-33. https://pubmed.ncbi.nlm.nih.gov/9474712

248. Anon. New triptans and other drugs for migraine. Med Lett Drugs Ther. 1998; 40:97-100. https://pubmed.ncbi.nlm.nih.gov/9793036

249. GlaxoSmithKline. Imitrex (sumatriptan) nasal spray prescribing information. Research Triangle Park, NC; 2012 Mar.

250. Novartis Pharmaceuticals. Migranal(dihydroergotamine mesylate) nasal spray prescribing information. East Hanover, NJ; 1997 Dec.

251. Diamond S. Recommendations for primary care providers: diagnosis and treatment of migraine. Headache Q. 1997; Suppl: 6-14.

252. Posner JB. Disorders of sensation. In: Wyngaarden JB, Smith LH Jr, Bennett JC, eds. Cecil textbook of medicine. 19th ed. Philadelphia: WB Saunders Company; 1992:2116-2123.

253. Raskin NH. Migraine and the cluster headache syndrome. In: Fauci AS, Braunwald E, Isselbacher KJ et al, eds. Harrison’s principles of internal medicine. 14th ed. New York: McGraw-Hill Company; 1998:2307-11.

254. May A, Bahra A, Büchel C et al. Hypothalamic activation in cluster headache attacks. Lancet. 1998; 352:275-8. https://pubmed.ncbi.nlm.nih.gov/9690407

255. Schoenen J. Cluster headaches—central or peripheral in origin? Lancet. 1998; 352:253-5.

256. Dahlof C. Placebo controlled trials with ergotamine in the acute treatment of migraine. Cephalalgia. 1993; 13:166-71. https://pubmed.ncbi.nlm.nih.gov/8358774

257. Lipton RB, Stewart WF, Ryan RE. Efficacy and safety of acetaminophen, aspirin, and caffeine in alleviating migraine headache pain.: three double-blind, randomized, placebo-controlled trials. Arch Neurol. 1998; 55:210-7. https://pubmed.ncbi.nlm.nih.gov/9482363

258. Brown GR. Stadol dependence: another case. JAMM. 1985; 254:910.

259. Austin RP. Diversion of butorphanol. Am J Hosp Pharm. 1983; 40:1306. https://pubmed.ncbi.nlm.nih.gov/6614013

260. Hoover RC, Williams RB. Survey of butorphanol and nalbuphine diversion in U.S. hospitals. Am J Hosp Pharm. 1985; 42:1111-3. https://pubmed.ncbi.nlm.nih.gov/4003423

261. Butorphanol. In: WHO Expert Committee on Durg Dependence. 25th report. Technical report series 775. Geneva: World Health Organization; 1989:24-6.

262. Glaxo Wellcome. Amerge (naratriptan hydrochloride) tablets prescribing information. Research Triangle Park, NC; 1998 Feb.

263. Merck & Co. Maxalt (rizatriptan benzoate) tablets prescribing information. West Point, PA; 1998 June.

264. Zeneca Pharmaceuticals. Zomig (zolmitriptan) tablets prescribing information. Wilmington, DE; 1997 Dec 1.

265. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis; a randomized controlled trial. Neurology. 1998; 50:466-70. https://pubmed.ncbi.nlm.nih.gov/9484373

266. Mattimoe D, Newton W. High-dose riboflavin for migraine prophylaxis. J Fam Pract. 1998; 47:11. https://pubmed.ncbi.nlm.nih.gov/9673596

267. Diener HC, Kaube H, Limmroth V. A practical guide to the management and prevention of migraine. Drugs. 1998; 56:811-24. https://pubmed.ncbi.nlm.nih.gov/9829155

268. Ramadan NM, Silberstein SD, Freitag FG et al. Evidence-based guidelines for migraine headache in the primary care setting: pharmacological management for prevention of migraine. St. Paul, MN; 2001. From the American Academy of Neurology website. http://www.aan.com

269. Matchar DB, Young WB, Rosenberg JH et al. Evidence-based guidelines for migraine headache in the primary care setting: pharmacological management of acute attacks. St. Paul, MN; 2001. From American Academy of Neurology web site. http://www.aan.com

270. Ryan R, Elkind A, Baker CC et al. Sumatriptan nasal spray for the acute treatment of migraine: Results of two clinical studies. Neurology. 1997; 49:1193-5. https://pubmed.ncbi.nlm.nih.gov/9371890

271. Diamond S, Elkind A, Jackson RT et al. Multiple-attack efficacy and tolerability of sumatriptan nasal spray in the treatment of migraine. Arch Fam Med. 1997; 130:1-12.

272. Food and Drug Administration. Public health advisory: combined use of 5-hydroxytryptamine receptor agonists (triptans), selective serotonin reuptake inhibitors (SSRIs) or selective serotonin/norepinephirne reuptake inhibitors (SNRIs) may result in life-threatening serotonin syndrome. Rockville, MD; 2006 Jul 19. From the FDA website: and http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/DrugSafetyInformationforHeathcareProfessionals/PublicHealthAdvisories/ucm124349.htmhttp://www.fda.gov/Drugs/DrugSafety/InformationbyDrugClass/ucm096273.htm). http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm150367.htm

276. Tepper SJ, Tepper DE. Breaking the cycle of medication overuse headache. Cleve Clin J Med. 2010; 77:236-42. https://pubmed.ncbi.nlm.nih.gov/20360117

277. Negro A, Martelletti P. Chronic migraine plus medication overuse headache: two entities or not?. J Headache Pain. 2011; 12:593-601. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208042/ https://pubmed.ncbi.nlm.nih.gov/21938457

278. Bijl D. The serotonin syndrome. Neth J Med. 2004; 62:309-13. https://pubmed.ncbi.nlm.nih.gov/15635814

279. Pfizer. Alsuma (sumatriptan succinate) injection prescribing information. New York, NY; 2012 Dec.

280. Zogenix, Inc. Sumavel DosePro (sumatriptan succinate) injection prescribing information. San Diego, CA; 2011 Jun.

281. GlaxoSmithKline. Treximet (sumatriptan succinate and naproxen sodium) tablets prescribing information. Research Triangle Park, NC; 2012 Oct.

282. Brandes JL, Kudrow D, Stark SR et al. Sumatriptan-naproxen for acute treatment of migraine: a randomized trial. JAMA. 2007; 297:1443-54. https://pubmed.ncbi.nlm.nih.gov/17405970

283. Sumatriptan. In: Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation: a reference guide to fetal and neonatal risk. 9th ed. Philadelphia: Lippincott Williams & Wilkins; 2011:1376-9.

284. GlaxoSmithKline. Patients instructions for use: Imitrex STATdose System. Research Triangle Park, NC; 2012.

285. Gregor N, Schlesiger C, Akova-Oztürk E et al. Treatment of cluster headache attacks with less than 6 mg subcutaneous sumatriptan. Headache. 2005; 45:1069-72.

286. Hurtukova D. Dear health care provider letter: Urgent—Zecuity (sumatriptan iontophoretic transdermal system) suspension of marketing. North Wales, PA: Teva Pharmaceuticals; 2016 Jun 10. From Zecuity website. https://www.zecuity.com/hcp/ZecuityDHCPLetter-MarketSuspensionJune102016.pdf

287. Food and Drug Administration. Zecuity (sumatriptan) migraine patch: Drug safety communication—FDA evaluating risk of burns and scars. Rockville, MD; 2016 Jun 13. From FDA website. https://www.fda.gov/safety/medwatch/safetyinformation/safetyalertsforhumanmedicalproducts/ucm504736.htm

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