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Brand name: Jetrea
Drug class: EENT Drugs, Miscellaneous
VA class: OP900
Chemical name: Micro-(synthetic human) plasmin
Molecular formula: C1214H1890N338O348S14
CAS number: 1048016-09-6

Medically reviewed by on Aug 25, 2022. Written by ASHP.


Recombinant truncated form of human plasmin (a serine protease); a vitreolytic agent.

Uses for Ocriplasmin

Vitreomacular Adhesion

Treatment of symptomatic vitreomacular adhesion (VMA).

Provides pharmacologic (nonsurgical) option for patients with less severe symptomatic VMA to receive treatment at an earlier stage and potentially avoid surgical complications.

Ocriplasmin Dosage and Administration


Ophthalmic Administration

Administer by intravitreal injection only into the affected eye by a qualified physician.

Must be diluted prior to intravitreal administration. Remove vial from freezer and allow contents to thaw at room temperature for several minutes. Once completely thawed, dilute with 0.2 mL of sterile, preservative-free 0.9% sodium chloride for injection. Gently swirl to mix contents.

Prior to intravitreal administration, withdraw entire contents of vial (0.4 mL) through a sterile 19-gauge needle into a 1-mL syringe (both provided by manufacturer ) using aseptic technique. Discard needle and replace with sterile 30-gauge needle (also provided by manufacturer ) for intravitreal injection. To obtain appropriate dose (0.125 mg), carefully expel air bubbles and excess drug until plunger tip is aligned with the line that marks 0.1 mL on the syringe. Use immediately because drug product contains no preservatives.

Inject under controlled aseptic conditions (including use of sterile gloves, sterile drape, and sterile eyelid speculum [or equivalent]) following adequate anesthesia and administration of a broad-spectrum anti-infective agent.

To administer intravitreally, insert 30-gauge injection needle 3.5–4 mm posterior to the limbus, aiming toward the center of vitreous cavity in order to deliver intended dose to the mid-vitreous. Avoid injecting into the horizontal meridian.

Monitor patients for elevation of IOP immediately following intravitreal injection; monitoring may include evaluation of optic nerve head perfusion or tonometry. A sterile paracentesis needle should be available.

Use each vial only for treatment of a single eye; discard any unused portion. If contralateral eye requires treatment, use a new vial; change sterile field, syringe, gloves, drape, eyelid speculum, and injection needle before administering into the other eye. (See Dosage under Dosage and Administration.)

Repeated administration in the same eye is not recommended.



Symptomatic Vitreomacular Adhesion
Ophthalmic Administration

Intravitreal injection: 0.125 mg (0.1 mL of diluted solution) into the affected eye once as a single dose. Repeated doses not recommended because of possible increased risk of lens subluxation. (See Lens Subluxation under Cautions.)

If contralateral eye requires treatment, wait >7 days after initial injection before administering to contralateral eye because monitoring of postinjection course (including potential for decreased vision) in injected eye is necessary.

Special Populations

Dosage modification not required based on age or gender.

Cautions for Ocriplasmin


  • Manufacturer states none known.


Decreased Vision

A decrease of ≥3 lines of best corrected visual acuity reported. The majority of cases were attributed to progression of VMA with traction; many such cases required surgical intervention. Monitor patients appropriately.

Intravitreal Injection-related Effects

Intraocular inflammation or infection, intraocular hemorrhage, and increased IOP reported. Most cases of intraocular inflammation were mild and transient.

Monitor patients for elevation of IOP immediately following intravitreal injection. (See Administration under Dosage and Administration.) Instruct patients to promptly report any symptoms suggestive of endophthalmitis or retinal detachment (e.g., eye pain or redness, photophobia, blurred or decreased vision).

Lens Subluxation

Lens subluxation reported in at least one patient who received an intravitreal dose of 0.175 mg (1.4 times the recommended dose). Lens subluxation also reported in animals receiving a single dose that produced vitreous concentrations 1.4 times those achieved with the recommended dose; in monkeys receiving a second intravitreal dose 28 days after the first dose, lens subluxation was reported in 100% of treated eyes.

Repeated administration in the same eye is not recommended.

Retinal Breaks

Retinal detachment and retinal tear (without detachment) reported following ocriplasmin treatment; occurred before, during, or after vitrectomy.


Dyschromatopsia, described as yellowish vision, reported. In approximately half of such cases, electroretinographic changes also reported.


As with all therapeutic proteins, potential for immunogenicity exists; however, immunogenicity to ocriplasmin not evaluated.

Specific Populations


Category C.


Not known whether ocriplasmin is distributed into milk. Caution if used in nursing women.

Pediatric Use

Safety and efficacy not established.

Geriatric Use

No substantial differences in efficacy or safety relative to younger patients.

Common Adverse Effects

Vitreous floaters, conjunctival hemorrhage, eye pain, photopsia, blurred vision, macular hole, reduced visual acuity, visual impairment, retinal edema.

Interactions for Ocriplasmin

No formal drug interaction studies to date.

Ocriplasmin Pharmacokinetics



The theoretical average vitreous concentration achieved immediately after intravitreal injection is approximately 29 mcg/mL (0.125 mg-dose delivered to 4.3 mL of vitreous volume).

Systemic concentrations expected to be low or undetectable following intravitreal injection because of the small dose (0.125 mg) administered.



Undergoes autolysis in vitreous. In systemic circulation, rapidly inactivated by protease inhibitor α2-antiplasmin or α2-macroglobulin of the endogenous protein catabolism pathway.

Following intravitreal injection in a limited number of patients undergoing vitrectomy, mean vitreous concentrations declined rapidly. At 24 hours postinjection, mean vitreous concentrations were <3% of the theoretical vitreous concentration achieved immediately after injection.

Elimination Route

Endogenous protein catabolism.





Frozen at or below −20°C. Protect from light. Store in original package until use.


  • Proteolytic enzyme; exhibits activity against protein components (e.g. collagen, fibronectin, laminin) of the vitreous body and the vitreoretinal interface.

  • Promotes liquefaction of the vitreous body and detachment of the vitreous from the retina (posterior vitreous detachment [PVD]) by dissolving the protein matrix responsible for VMA.

Advice to Patients

  • Risk of intraocular inflammation or infection. Importance of patients informing their ophthalmologist immediately if change in vision occurs or if the treated eye becomes red, sensitive to light, or painful.

  • Possible risk of temporary visual impairment after intravitreal injection; importance of avoiding driving a vehicle or operating heavy machinery until visual impairment has resolved. If visual impairment persists or worsens, importance of seeking care from an ophthalmologist.

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.

  • Importance of informing patients of other precautionary information. (See Cautions.)


Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Ocriplasmin (Recombinant)


Dosage Forms


Brand Names



Injection, for intravitreal use only

2.5 mg/mL (0.5 mg/0.2 mL)



AHFS DI Essentials™. © Copyright 2023, Selected Revisions September 4, 2013. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

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