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Ocriplasmin ophthalmic Side Effects

Medically reviewed by Last updated on Aug 20, 2020.

In Summary

More frequently reported side effects include: decreased visual acuity and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocriplasmin ophthalmic: intraocular solution

Side effects requiring immediate medical attention

Along with its needed effects, ocriplasmin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocriplasmin ophthalmic:

More common

  • Bloody eyes
  • blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • seeing flashes or sparks of light
  • sensitivity of the eye to light
  • tearing

Less common

  • Change in color vision
  • difficulty seeing at night
  • eye discomfort
  • loss of vision
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • throbbing pain

Side effects not requiring immediate medical attention

Some side effects of ocriplasmin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Dry eyes

For Healthcare Professionals

Applies to ocriplasmin ophthalmic: intravitreal solution


The most commonly reported side effects included vitreous floaters, eye pain, photopsia, and blurred vision.[Ref]


Very common (10% or more): Vitreous floaters (up to 16.8%), macular hole (up to 15.8%), eye pain (up to 13.1%), photopsia (up to 11.8%), chromatopsia, conjunctival hemorrhage

Common (1% to 10%): Abnormal optical coherence tomography (OCT), anterior chamber cell, anterior chamber flare, blurred vision, conjunctival edema, conjunctival hyperemia, cystoid macular edema, decreased best corrected visual acuity (BCVA), dry eye, dyschromatopsia, eye irritation, eye pruritus, eyelid edema, foreign body sensation in eyes, increased intraocular pressure, increased lacrimation, iritis, macular degeneration, macular edema, metamorphopsia, ocular discomfort, ocular hyperemia, photophobia, photopsia, reduced visual acuity, retinal breaks, retinal degeneration, retinal edema, retinal hemorrhage, retinal pigment epitheliopathy, subretinal fluid, visual impairment, vitreous detachment, vitreous hemorrhage, vitritis

Uncommon (0.1% to 1%): Anterior chamber inflammation, conjunctival irritation, corneal abrasion, diplopia, eye inflammation, hyphema, lens subluxation, miosis, night blindness, retinal detachment, retinal tear, serious acute visual impairment, severe acute visual impairment, transient blindness, unequal pupils

Frequency not reported: Dim vision, macular hole progression

Postmarketing reports: Impaired pupillary reflex[Ref]

Nervous system

Very common (10% or more): Abnormal color vision test, abnormal retinogram

Common (1% to 10%): Abnormal macular reflex, increased intraocular pressure, visual field defect, visual symptoms perceived in the contralateral eye

Frequency not reported: Scotoma[Ref]


Common (1% to 10%): Intravitreal injection procedure associated effects[Ref]


Frequency not reported: Immunogenicity[Ref]


1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Jetrea (ocriplasmin ophthalmic)." ThromboGenics Inc, Iselin, NJ.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.