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Ocriplasmin ophthalmic Side Effects

In Summary

More frequently reported side effects include: decreased visual acuity and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocriplasmin ophthalmic: intraocular solution

Along with its needed effects, ocriplasmin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocriplasmin ophthalmic:

More Common

  • Bloody eyes
  • blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • seeing flashes or sparks of light
  • sensitivity of the eye to light
  • tearing

Less Common

  • Change in color vision
  • difficulty seeing at night
  • eye discomfort
  • loss of vision
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • throbbing pain

Some side effects of ocriplasmin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less Common

  • Dry eyes

For Healthcare Professionals

Applies to ocriplasmin ophthalmic: intravitreal solution


The most commonly reported side effects included vitreous floaters, eye pain, photopsia, and blurred vision.[Ref]


Very common (10% or more): Vitreous floaters (up to 16.8%), eye pain (up to 13.1%), photopsia (up to 11.8%)

Common (1% to 10%): Abnormal color vision test/abnormal Roth 28-hue color vision test, abnormal macular reflex, abnormal optical coherence tomography (OCT), abnormal retinogram, anterior chamber cell, anterior chamber flare, blurred vision, chromatopsia, conjunctival edema, conjunctival hemorrhage, conjunctival hyperemia, cystoid macular edema, decrease in a-/b-wave amplitude, decreased vision, dim vision, dry eye, dyschromatopsia, electroretinographic (ERG) changes, eye irritation, eye pruritus, eyelid edema, foreign body sensation in eye, incomplete inner segment/outer segment (IS/OS) band, increased intraocular pressure, increased lacrimation, intraocular hemorrhage, intraocular inflammation, iritis, macular degeneration, macular edema, macular hole (new onset/worsening), metamorphopsia, ocular discomfort, ocular hyperemia, photophobia, reduced visual acuity, retinal breaks/detachment/tears, retinal degeneration, retinal edema, retinal hemorrhage, retinal pigment epitheliopathy, subretinal fluid, visual field defect, visual impairment, vitreomacular adhesion/vitreomacular traction worsening, vitreous adhesions, vitreous detachment, vitreous hemorrhage, vitreitis, yellowish vision

Uncommon (0.1% to 1%): Anterior chamber inflammation, conjunctival irritation, corneal abrasion, diplopia, eye inflammation, hyphema, impaired pupillary reflex, lens subluxation, longer-term reduced visual acuity, miosis, night blindness, serious/severe acute visual impairment, transient blindness, unequal pupils

Frequency not reported: Cataract, visual symptoms perceived in the contralateral eye[Ref]

Nervous system

Common (1% to 10%): Scotoma[Ref]


Frequency not reported: Immunogenicity[Ref]


Common (1% to 10%): Intravitreal injection procedure associated effects[Ref]


1. "Product Information. Jetrea (ocriplasmin ophthalmic)." ThromboGenics Inc, Iselin, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

More about ocriplasmin ophthalmic

Consumer resources

Other brands: Jetrea

Professional resources

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