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Ocriplasmin ophthalmic Side Effects

In Summary

More frequently reported side effects include: decreased visual acuity and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocriplasmin ophthalmic: intraocular solution

As well as its needed effects, ocriplasmin ophthalmic may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking ocriplasmin ophthalmic, check with your doctor or nurse immediately:

More common:
  • Bloody eyes
  • blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • seeing flashes or sparks of light
  • sensitivity of the eye to light
  • tearing
Less common:
  • Change in color vision
  • difficulty seeing at night
  • eye discomfort
  • loss of vision
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • throbbing pain

Minor Side Effects

Some ocriplasmin ophthalmic side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Dry eyes

For Healthcare Professionals

Applies to ocriplasmin ophthalmic: intravitreal solution


Very common (10% or more): Vitreous floaters, eye pain, conjunctival hemorrhage
Common (1% to 10%): Intraocular inflammation, decreased best corrected visual acuity (BCVA), increased intraocular pressure, intraocular hemorrhage, dyschromatopsia, retinal tear, retinal detachment, macular edema, anterior chamber cell, photophobia, vitreous detachment, ocular discomfort, iritis, cataract, dry eye, metamorphopsia, conjunctival hyperemia, retinal degeneration, visual impairment, blurred vision, retinal hemorrhage, vitreous hemorrhage, macular hole, macular degeneration, retinal edema, retinal pigment epitheliopathy, vitreous adhesions, conjunctival edema, eyelid edema, vitritis, anterior chamber flare, ocular sensation in eyes, eye pruritus
Uncommon (0.1% to 1%): Transient blindness, lens subluxation, scotoma, visual field defect, diplopia, hyphema, miosis, unequal pupils, corneal abrasion, anterior chamber inflammation, eye inflammation, conjunctival irritation
Frequency not reported: Night blindness[Ref]


1. "Product Information. Jetrea (ocriplasmin ophthalmic)." ThromboGenics Inc, Iselin, NJ.

It is possible that some side effects of ocriplasmin ophthalmic may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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