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Ocriplasmin ophthalmic Side Effects

In Summary

More frequently reported side effects include: decreased visual acuity and intraocular inflammation. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ocriplasmin ophthalmic: intraocular solution

Along with its needed effects, ocriplasmin ophthalmic may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ocriplasmin ophthalmic:

More common
  • Bloody eyes
  • blurred vision or other change in vision
  • decreased vision
  • eye pain
  • redness of the eye
  • seeing flashes or sparks of light
  • sensitivity of the eye to light
  • tearing
Less common
  • Change in color vision
  • difficulty seeing at night
  • eye discomfort
  • loss of vision
  • seeing floating spots before the eyes, or a veil or curtain appearing across part of vision
  • throbbing pain

Some side effects of ocriplasmin ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common
  • Dry eyes

For Healthcare Professionals

Applies to ocriplasmin ophthalmic: intravitreal solution


Very common (10% or more): Vitreous floaters, eye pain, conjunctival hemorrhage
Common (1% to 10%): Intraocular inflammation, decreased best corrected visual acuity (BCVA), increased intraocular pressure, intraocular hemorrhage, dyschromatopsia, retinal tear, retinal detachment, macular edema, anterior chamber cell, photophobia, vitreous detachment, ocular discomfort, iritis, cataract, dry eye, metamorphopsia, conjunctival hyperemia, retinal degeneration, visual impairment, blurred vision, retinal hemorrhage, vitreous hemorrhage, macular hole, macular degeneration, retinal edema, retinal pigment epitheliopathy, vitreous adhesions, conjunctival edema, eyelid edema, vitritis, anterior chamber flare, ocular sensation in eyes, eye pruritus
Uncommon (0.1% to 1%): Transient blindness, lens subluxation, scotoma, visual field defect, diplopia, hyphema, miosis, unequal pupils, corneal abrasion, anterior chamber inflammation, eye inflammation, conjunctival irritation
Frequency not reported: Night blindness[Ref]


1. "Product Information. Jetrea (ocriplasmin ophthalmic)." ThromboGenics Inc, Iselin, NJ.

Some side effects of ocriplasmin ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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