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Ocriplasmin Ophthalmic Dosage

Applies to the following strengths: 0.5 mg/0.2 mL; 0.375 mg/0.3 mL

Usual Adult Dose for Vitreomacular Adhesion

0.125 mg (0.1 mL of the diluted solution) via intravitreal injection to the affected eye ONCE as a single dose

Comments:

  • Each drug vial should only be used once and for the treatment of a single eye.
  • This drug should be administered by a qualified physician.
  • The manufacturer product information should be consulted regarding administration.

Use: Treatment of symptomatic vitreomacular adhesion

Renal Dose Adjustments

No adjustment recommended.

Liver Dose Adjustments

No adjustment recommended.

Precautions

CONTRAINDICATIONS: None.

This drug is not recommended for use in children.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

  • Repeated administration in the same eye is not recommended.
  • Perioperative antibiotic drops may be administered at the discretion of the treating ophthalmologist.

Storage requirements:
  • Freeze and store in the original package to protect from light.
  • Do not refreeze a vial once it has been thawed.

Reconstitution/preparation techniques:
  • Thaw at room temperature and dilute before use.
  • The manufacturer product information should be consulted.

General:
  • Treatment in the contralateral eye is not recommended concurrently or within 7 days of the initial injection in order to monitor the post-injection course, including the potential for decreased vision in the injected eye.
  • As a therapeutic protein, this drug has immunogenicity potential but has not undergone evaluation in this area.
  • There are no clinical data on concomitant use with VEGF-inhibitors.

Monitoring:
  • Immediately following the intravitreal injection, patients should be monitored for side effects such as intraocular inflammation/infection, elevation in intraocular pressure, and decrease in visual acuity.

Patient advice:
  • Seek immediate care from your eye doctor if you have any vision or eye problems such as redness, light sensitivity, pain, and vision change following the drug injection.
  • Do not drive or use machines directly following the drug injection as you may experience temporary vision problems. Promptly contact your eye doctor if your vision problems persist or become worse.

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Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.