Can you take Rybelsus if you are not diabetic?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 8, 2025.

Official Answer by Drugs.com

Rybelsus (semaglutide) is FDA-approved only for adults with type 2 diabetes to help manage blood sugar levels alongside diet and exercise. It is not approved for use in non-diabetic individuals, though healthcare providers may sometimes prescribe it off-label for other conditions, such as weight management.

Off-Label Use for Weight Loss

Although not officially approved for weight loss, some healthcare providers may prescribe Rybelsus off-label for individuals who are overweight or obese, particularly those with related health conditions.

A clinical study (OASIS 1) with 709 participants found that adults without type 2 diabetes who took oral semaglutide daily experienced greater weight loss compared to those on a placebo. Reported side effects were similar to those seen in studies looking at people with type 2 diabetes, and mainly consisted of stomach-related side effects. The dose taken for weight loss in this study was much higher than what is FDA-approved for type 2 diabetes.

While Rybelsus shows potential for weight loss in non-diabetics, it should only be taken under medical supervision due to possible side effects and the need for appropriate dosing. Always consult a healthcare provider before using Rybelsus for any off-label purpose.

This is not all the information you need to know about Rybelsus (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.

References

Knop, F. K., et. al. 2023. Oral semaglutide 50 mg taken once per day in adults with overweight or obesity (OASIS 1): a randomised, double-blind, placebo-controlled, phase 3 trial. In: The Lancet. DOI: https://doi.org/10.1016/s0140-6736(23)01185-6

Kommu, S., et. al. Semaglutide. 2024. In: StatPearls [Internet]. Accessed 03/08/2025 at https://www.ncbi.nlm.nih.gov/books/NBK603723/

Rybelsus [package insert]. Updated December 2024. Novo Nordisk. Accessed 03/07/2025 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=27f15fac-7d98-4114-a2ec-92494a91da98

Liraglutide vs Semaglutide: How do they compare?

Both liraglutide and semaglutide are GLP-1 receptor agonist prescription medicines used to help lower blood sugar in eligible patients with type 2 diabetes, to help people lose weight and keep it off, and to help lower the risk of major heart-related events like a stroke, heart attack or death. Common brand names include Ozempic and Wegovy (semaglutide) and Saxenda and Victoza (liraglutide).

Rybelsus vs Ozempic for weight loss: Which to choose?

Both Rybelsus and Ozempic are FDA approved to treat adults with Type 2 diabetes, but can cause weight loss as a side effect. In separate clinical trials, patients lost up to 3.7 kg (8 lbs) over 26 weeks of taking Rybelsus, and up to 4.7 kg (10 lbs) over 30 weeks with Ozempic. Continue reading

What foods should I eat or avoid when taking Rybelsus?

There are no specific foods to avoid, but if you are being treated for type 2 diabetes you should avoid regular consumption of foods high in fat, sugar and calories. Rybelsus works best if you combine it with a healthy diet and exercise plan as recommended by your healthcare provider. Continue reading

Can you take Rybelsus if you are not diabetic?

Off-Label Use for Weight Loss

Read next

Liraglutide vs Semaglutide: How do they compare?

Rybelsus vs Ozempic for weight loss: Which to choose?

What foods should I eat or avoid when taking Rybelsus?

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