What is the difference between Eylea and Eylea HD?
Eylea HD is a higher dose, longer-acting formulation of Eylea that has been approved to treat Neovascular (Wet) Age-Related Macular Degeneration (wAMD), Diabetic Macular Edema (DME), and Diabetic Retinopathy (DR). Eylea is approved to treat these conditions in addition to Macular Edema Following Retinal Vein Occlusion (RVO) and Retinopathy of Prematurity (ROP).
Both are eye injections, but after an initial dosing period, Eylea HD does not have to be given as often as Eylea. Eylea HD is usually administered once every 8 to 12 weeks for DR or 8 to 16 weeks for wAMD and DME. Eylea is usually administered every 4 weeks, which may be extended to once every 8 weeks (2 months), depending on the condition.
Eylea was first approved on November 18, 2011, and Eylea HD was first approved on August 18, 2023.
Both Eylea and Eylea HD are made by Regeneron and there are no differences in their warnings, side effects, interactions, storage, and the way they work.
References
- Eylea HD Prescribing Information. https://www.regeneron.com/downloads/eyleahd_fpi.pdf
- Eylea Prescribing Information. https://www.regeneron.com/downloads/eylea_fpi.pdf
Read next
What is the difference between Vabysmo and Eylea?
Vabysmo (faricimab) targets vascular endothelial growth factor (VEGF) and angiopoietin-1, whereas Eylea (afibercept) targets VEGF and placental growth factor (P1GF). Both agents are used to treat conditions such as macular degeneration (AMD) and diabetic macular edema and are given by intravitreal injection (into the gel part of the eye). Continue reading
What’s the difference between Eylea, Eylea HD, and Avastin?
Eylea, Eylea HD, and Avastin may all be used to treat neovascular (wet) age-related macular degeneration (AMD), as injections into the eye (intravitreal injections). Both Eylea and Eylea HD are FDA-approved for this indication, but use of Avastin is off-label (not an FDA-approved indication - although it has been used for this purpose since 2005). Eylea HD is a longer acting version of Eylea. Continue reading
What are anti-VEGF drugs (VEGF inhibitors)?
Anti-VEGF drugs slow the abnormal growth of blood vessels associated with certain cancers and degenerative eye conditions, such as age-related macular degeneration. Anti-VEGF stands for anti-vascular endothelial growth factor. Continue reading
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