What is Ozempic used for and how does it work?

Key Points

• Ozempic (generic name: semaglutide) is medication used alongside diet and exercise to improve blood sugar control in adults with type 2 diabetes. Ozempic is not used to treat type 1 diabetes. You may use Ozempic in addition to other diabetes medications such as metformin or insulin.
• Ozempic is also approved to reduce the risk of major cardiovascular (heart and blood vessel) events such as heart attack, stroke, or death in adults with type 2 diabetes and known heart disease.
• It's also approved by the FDA to reduce the risk of worsening kidney disease and cardiovascular death in patients with type 2 diabetes

The most common side effects include nausea, vomiting, diarrhea, stomach pain and constipation.

Ozempic is given as an injection under your skin once a week. Your health care provider can teach you how to do this yourself using the pen injector.

What is the mechanism of action for Ozempic?

Ozempic is in a class of drugs known as glucagon-like peptide-1 (GLP-1) agonists (incretin mimetics). It's active ingredient is known as semaglutide.

Ozempic works by binding to GLP-1 receptors and stimulates insulin release from the pancreas when you need it. It helps to lower your blood sugar levels and A1C and helps to reduce the amount of sugar released by your liver. It slows down food leaving your stomach to help prevent blood sugar spikes and makes you feel fuller for a longer period of time. This can help reduce your appetite.

Will I lose weight with Ozempic?

Ozempic is not approved by the FDA for weight loss. However, when you use it for type 2 diabetes, you may lose weight.

In studies over 56 weeks, adults who weighed an average of 197 lbs (89.5 kg) lost 9 to 12 lbs (4 to 5.5 kg), although some patients gained weight, too.

How does Ozempic come at the pharmacy?

Ozempic (semaglutide), from Novo Nordisk, is available as pre-filled pens that deliver a 0.25 mg, 0.5 mg, 1 mg or 2 mg dose per injection, based on how your doctor prescribes it. It comes in a carton with one pen, and once you reach your regular maintenance does, each pen should last about one month.

Each carton also comes with the NovoFine Plus needles you will need for your injection.

What is the normal dose of Ozempic?

Ozempic is injected subcutaneously (under the skin) in the stomach area, thigh, or upper arm. Your doctor, nurse or pharmacist will teach you how to do this. Don’t inject it into a muscle or vein. Each pen is for use only by a single patient.

Ozempic injection is given only once a week on the same day of the week, at any time on that day. You might want to add this to your calendar. You can take Ozempic with or without food.

• The recommended starting dose of Ozempic is a 0.25 mg injection once weekly for 4 weeks. This is only a starting dose and cannot be used long-term to control your blood sugar.
• After 4 weeks, you go up to the 0.5 mg dose once a week for at least 4 weeks.
• If you need more blood sugar control after 4 weeks, your doctor may decide to increase your dose. The maximum dose of Ozempic is 2 mg per week.
• After initial starting doses, the maintenance (long-term) dose to reduce the risk of worsening kidney disease and cardiovascular death in patients with type 2 diabetes is 1 mg subcutaneously per week.

Related questions

• Mounjaro vs Ozempic: Which is right for you?
• Ozempic Side Effects to Watch For
• What are the long-term side effects of Ozempic?

Can I change the day of the week I use Ozempic?

Yes, you may change the day of the week you use Ozempic as long as your last dose was taken 2 or more days (at least 48 hours) before you make the change. Be sure to adjust your calendar.

If you miss a dose of Ozempic, take the missed dose as soon as possible within 5 days after the missed dose. If more than 5 days have passed, skip the missed dose and take your next dose on the regularly scheduled day.

Do I have to keep Ozempic in the fridge?

Once you get your Ozempic pen from the pharmacy, you should keep it in the refrigerator (between 36°F to 46°F / 2°C to 8°C) when it’s new and unused.

Once you’ve used it the first time, you can store your pen for 56 days at room temperature (between 59ºF to 86ºF / 15ºC to 30ºC) or you can still keep it on the refrigerator for 56 days. Don’t freeze the pen or use it if it has been frozen. Keep the pen cap on when it is not in use.

The Ozempic pen you are using should be disposed of (thrown away) after 56 days (whether kept in the fridge or at room temperature), even if it still has Ozempic left in it. Write the disposal date on your calendar to help keep track.

Do not store Ozempic pens directly next to the cooling element in your refrigerator. Keep Ozempic away from heat and out of the light. Don't leave it in the car where it can get too hot or cold, either.

Bottom Line

• Ozempic (semaglutide) is an injectable medication used to treat type 2 diabetes. It is in a class of drugs known as glucagon-like peptide-1 (GLP-1) agonists (incretin mimetics).
• Ozempic can also lower the risk of a major cardiovascular (heart and blood vessel) events such as a heart attack, stroke, or death and can help to reduce the risk of worsening kidney disease and cardiovascular death in patients with type 2 diabetes
• It works in several ways: it stimulates insulin release to lower your blood sugar when you need it, helps to reduce the amount of sugar released by your liver, and slows down the rate that food leaves your stomach to help prevent blood sugar spikes, which can help control your hunger.

This is not all the information you need to know about Ozempic for safe and effective use and does not replace your healthcare providers instructions. Review the full product information and discuss this information with your doctor or other health care provider.

Read next

See also:

Related medical questions

• How many doses are in an Ozempic pen?
• Do Ozempic, Wegovy, Mounjaro & Zepbound cause hair loss?
• How does Ozempic work for weight loss?
• What happens when you stop taking Ozempic?
• Can you switch between Ozempic and Mounjaro?
• Does Ozempic need to be refrigerated?
• Saxenda vs Ozempic: For Weight Loss?
• Will my insurance cover the cost of Ozempic?
• Can you buy Ozempic over the counter?
• When is the best time of day to take Ozempic?
• Why am I not losing weight on Ozempic?
• Does Ozempic cause muscle loss and how to prevent it?
• Where and how should Ozempic be injected?
• Rybelsus vs Ozempic for weight loss: Which to choose?
• Are there natural alternatives to Ozempic for weight loss?
• Ozempic Face: What causes it and how to prevent it?
• How long does Ozempic last in your system?
• Do GLP-1 drugs like Ozempic and Mounjaro cause sulfur burps?
• How long can you stay on Ozempic?
• How does Ozempic affect blood pressure?
• Is Ozempic better than metformin?
• Trulicity vs Ozempic: Which is right for you?
• Taking Ozempic: What foods should you avoid?

Drug information

• Ozempic Information for Consumers
• Ozempic prescribing info & package insert (for Health Professionals)
• Side Effects of Ozempic (detailed)
• Ozempic user reviews (1,544)

Related support groups

• Ozempic (107 questions, 223 members)
• Diabetes, Type 2 (502 questions, 1,428 members)
• Weight Loss (Obesity/Overweight) (848 questions, 1,510 members)
• Cardiovascular Risk Reduction (100 questions, 28 members)
• Chronic Kidney Disease (42 questions, 105 members)

Medical Disclaimer