Is Ozempic safe after gastric bypass or sleeve surgery?

Ozempic (semaglutide) can be used after bariatric surgery, including gastric bypass and sleeve gastrectomy, to help prevent weight regain. It is a glucagon-like peptide-1 (GLP-1) receptor agonist approved for type 2 diabetes, but is often prescribed off-label for weight loss.

While large-scale studies on Ozempic’s safety after bariatric surgery are limited, existing research suggests that its side effects are similar to those experienced by individuals who have not had weight-loss surgery. Your healthcare provider can help determine if Ozempic is right for you.

Can You Take Ozempic After Gastric Bypass or Sleeve Surgery?

Studies indicate that semaglutide is safe and effective for weight loss in patients who have undergone bariatric surgery. However, it may not be suitable for everyone, particularly those with:

• A history of pancreatitis
• A personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia syndrome type 2 (MEN2)

Your doctor can assess whether Ozempic or a similar medication is appropriate based on your medical history.

How Effective Is Ozempic for Weight Loss After Bariatric Surgery?

Several studies suggest Ozempic helps patients manage weight regain after weight-loss surgery:

• One small study found that patients without type 2 diabetes lost about 10% of their body weight within six months of starting Ozempic, typically around five years post-surgery. Common side effects included nausea and a temporary rise in pancreatic lipase levels.
• Another observational study showed that 50% of participants lost 10% or more of their body weight after six months of weekly 1 mg semaglutide injections. Most reported mild, temporary gastrointestinal side effects.

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How Does Ozempic Help With Weight Loss?

Ozempic mimics the natural glucagon-like peptide-1 (GLP-1) hormone in the body, activating receptors that regulate appetite and digestion. It aids weight loss by:

• Slowing digestion, leading to prolonged fullness
• Reducing appetite, which lowers calorie intake over time

What Are the Side Effects of Ozempic?

Ozempic commonly causes gastrointestinal side effects, including:

• Nausea (up to 20%)
• Vomiting (up to 9%)
• Diarrhea (up to 9%)
• Stomach pain (up to 7%)
• Constipation (up to 5%)

These are not all possible side effects. Consult your healthcare provider and review the product information for a complete list.

This is not all the information you need to know about Ozempic (semaglutide) for safe and effective use and does not take the place of your doctor’s directions. Review the full product information and discuss this information and any questions you have with your doctor or other health care provider.