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Does Lybalvi cause weight gain?

Medically reviewed by Kristianne Hannemann, PharmD. Last updated on March 27, 2025.

Official Answer by Drugs.com

Key Points

Can Lybalvi Cause Weight Gain?

Yes, weight gain is a possible side effect of Lybalvi. In a 4-week clinical trial, 19% of people taking Lybalvi reported weight gain, compared to 3% of those on a placebo. In a 24-week study, 25% of users reported weight gain.

How Much Weight Might I Gain on Lybalvi?

Not everyone will gain weight from taking Lybalvi. The amount of weight you may gain depends on factors such as your starting weight, diet, exercise habits, other medications, and how long you are taking Lybalvi.

Clinical Trial Data

During a 4-week study of adults with schizophrenia:

In a 24-week clinical trial, patients taking Lybalvi gained around 4.2% of their starting body weight. Around 18% of people taking Lybalvi saw a 10% increase or more in their body weight.

Related questions

How Can I Prevent Weight Gain on Lybalvi?

While weight gain may not always be preventable, certain lifestyle adjustments can help minimize it:

If you notice you are gaining weight while taking Lybalvi, tell your healthcare provider.

This is not all the information you need to know about Lybalvi (olanzapine and samidorphan) for safe and effective use. Review the full Lybalvi (olanzapine and samidorphan) information, and discuss this information and any questions with your doctor or other health care provider.

References

Lybalvi [package insert]. Updated January 2024. Alkermes, Inc. Accessed September 23, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=32ffddd1-4e2b-45d9-9b36-bb730167ec80

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