Does Lybalvi cause weight gain?
Key Points
- Weight gain is a possible side effect of Lybalvi (olanzapine and samidorphan).
- Clinical trials show that up to 25% of users experience weight gain.
- Lifestyle changes may help reduce the risk of weight gain.
Can Lybalvi Cause Weight Gain?
Yes, weight gain is a possible side effect of Lybalvi. In a 4-week clinical trial, 19% of people taking Lybalvi reported weight gain, compared to 3% of those on a placebo. In a 24-week study, 25% of users reported weight gain.
How Much Weight Might I Gain on Lybalvi?
Not everyone will gain weight from taking Lybalvi. The amount of weight you may gain depends on factors such as your starting weight, diet, exercise habits, other medications, and how long you are taking Lybalvi.
Clinical Trial Data
During a 4-week study of adults with schizophrenia:
- Lybalvi users gained an average of 3 kg (6.6 lbs).
- Olanzapine users gained 2.4 kg (5.3 lbs).
- Placebo users gained 0.2 kg (0.4 lbs).
In a 24-week clinical trial, patients taking Lybalvi gained around 4.2% of their starting body weight. Around 18% of people taking Lybalvi saw a 10% increase or more in their body weight.
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How Can I Prevent Weight Gain on Lybalvi?
While weight gain may not always be preventable, certain lifestyle adjustments can help minimize it:
- Maintain a balanced diet while avoiding processed foods.
- Be mindful of portion sizes when eating meals.
- Keep up a regular exercise routine.
If you notice you are gaining weight while taking Lybalvi, tell your healthcare provider.
This is not all the information you need to know about Lybalvi (olanzapine and samidorphan) for safe and effective use. Review the full Lybalvi (olanzapine and samidorphan) information, and discuss this information and any questions with your doctor or other health care provider.
References
Lybalvi [package insert]. Updated January 2024. Alkermes, Inc. Accessed September 23, 2024 at https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=32ffddd1-4e2b-45d9-9b36-bb730167ec80
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Drug information
- Lybalvi Information for Consumers
- Lybalvi prescribing info & package insert (for Health Professionals)
- Side Effects of Lybalvi (detailed)
- Lybalvi user reviews (16)
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