When do the Eylea and Eylea HD patents expire?
Eylea and Eylea HD patents are due to run out from 2023 to 2039; however, these should not be taken as definite dates as there are many ways drug companies can extend their patents, for example, by changing the formulation of their product. For example, the original patent term for Regeneron was extended from May 23, 2020, to June 16, 2023.
The current patent expiry dates for Eylea are as follows:
- Composition of matter (for a composition of at least 2 ingredients): June 16, 2023
- Formulation patents (4 of these): June 14, 2027 (for 2); June 21, 2027; March 22, 2026
- Methods of treatment patents (3 of these): March 22, 2026, and January 11, 2032 (for 2)
- Method of manufacturing: March 22, 2026
- Composition of matter (supplementary protection certificate): May 23, 2025.
At least 5 Eylea HD patents are the same as Eylea patents, typically extending the patent expiry date.
- One new patent, US11103552B2 which relates to high concentration VEGF receptor fusion protein containing formulations, has a patent expiry date of 15 May 2039.
Because pharmaceutical companies make about 80% of their overall revenue while their drug is on patent, they will often try many legal techniques to extend their patents for as long as they can. Once patents fully expire, generic companies can copy the formulation, saving the cost of years of research, and undercutting the original company’s prices significantly.
References
- Regeneron reports second quarter 2023 financial and operating results. August 3, 2023. https://investor.regeneron.com/news-releases/news-release-details/regeneron-reports-second-quarter-2023-financial-and-operating
- Drug Patent Life: How Long Do Drug Patents Last? https://www.drugpatentwatch.com/blog/how-long-do-drug-patents-last/#:~:text=New%20Formulations%2C%20Administration%20Techniques%2C%20or,companies%20reformulate%20products%2C%20for%20example
- Use of a VEGF antagonist to treat angiogenic eye disorders. https://patents.google.com/patent/US9254338B2/en10
- Representative Regeneron U.S. Product Related Patents. Regeneron. https://www.regeneron.com/downloads/us-patent-products.pdf
Read next
What is the difference between Vabysmo and Eylea?
Vabysmo (faricimab) targets vascular endothelial growth factor (VEGF) and angiopoietin-1, whereas Eylea (afibercept) targets VEGF and placental growth factor (P1GF). Both agents are used to treat conditions such as macular degeneration (AMD) and diabetic macular edema and are given by intravitreal injection (into the gel part of the eye). Continue reading
What’s the difference between Eylea, Eylea HD, and Avastin?
Eylea, Eylea HD, and Avastin may all be used to treat neovascular (wet) age-related macular degeneration (AMD), as injections into the eye (intravitreal injections). Both Eylea and Eylea HD are FDA-approved for this indication, but use of Avastin is off-label (not an FDA-approved indication - although it has been used for this purpose since 2005). Eylea HD is a longer acting version of Eylea. Continue reading
What are anti-VEGF drugs (VEGF inhibitors)?
Anti-VEGF drugs slow the abnormal growth of blood vessels associated with certain cancers and degenerative eye conditions, such as age-related macular degeneration. Anti-VEGF stands for anti-vascular endothelial growth factor. Continue reading
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Drug information
- Eylea Information for Consumers
- Eylea prescribing info & package insert (for Health Professionals)
- Side Effects of Eylea (detailed)
- Eylea user reviews (72)
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