How does Benlysta work for lupus?
Benlysta works by attaching to a specific protein, called B-lymphocyte stimulator (BLyS), preventing it from binding to its receptors on B cells. BLyS is important for the growth and development of B cells, and B cells have a crucial role in the development of lupus. Certain B cells, called autoreactive B-cells, stay in the body for longer than they should in people with lupus, producing autoantibodies that target important cellular components, such as DNA, causing disease flares. By binding to BLyS, Benlysta prevents the survival of B-cells and their differentiation into immunoglobulin-producing plasma cells.
Benlysta is a biologic therapy, not a steroid. It may be called a B-cell depleting therapy or a selective immunosuppressant.
References
Benlysta (belimumab). Updated 04/2024. FDA Package Insert. https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/761043s027lbl.pdf
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What is the difference between Benlysta and Saphnelo?
Both Benlysta and Saphnelo are targeted treatments that may be used to treat systemic lupus erythematosus (SLE) in addition to standard therapy. But their approved indications, recommended target age groups, and the way they work, differ. They are the only two medicines to have been approved to treat SLE since the 1950s.
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What's the difference between Lupkynis and Benlysta?
Benlysta subcutaneous or intravenous injection is approved to treat adults and children 5 years of age and older with systemic lupus erythematosus (SLE) and active lupus nephritis (lupus-related kidney inflammation), while Lupkynis oral capsules are only approved to treat lupus nephritis in adults. Lupkynis has not yet been approved for use in children.
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Does Benlysta cause weight gain?
Although weight gain is not listed as a side effect of Benlysta in the product information, a phase IV clinical study that analyzed side effect information from 14,100 people who had taken Benlysta reported weight gain as a side effect for 2.87% of them (404 people). Continue reading
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