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How does Benlysta work for lupus?

Medically reviewed by Carmen Pope, BPharm. Last updated on Nov 8, 2024.

Official Answer by Drugs.com

Benlysta works by attaching to a specific protein, called B-lymphocyte stimulator (BLyS), preventing it from binding to its receptors on B cells. BLyS is important for the growth and development of B cells, and B cells have a crucial role in the development of lupus. Certain B cells, called autoreactive B-cells, stay in the body for longer than they should in people with lupus, producing autoantibodies that target important cellular components, such as DNA, causing disease flares. By binding to BLyS, Benlysta prevents the survival of B-cells and their differentiation into immunoglobulin-producing plasma cells.

Benlysta is a biologic therapy, not a steroid. It may be called a B-cell depleting therapy or a selective immunosuppressant.

References

Benlysta (belimumab). Updated 04/2024. FDA Package Insert.  https://www.accessdata.fda.gov/drugsatfda_docs/label/2024/761043s027lbl.pdf

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