Drug Interaction Report

SORAfenib may increase the blood levels of DOXOrubicin. This may increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, mouth sores, heart problems, and impaired bone marrow function resulting in low numbers of different types of blood cells. You may also be more likely to experience anemia, bleeding problems, or infections due to low blood cell counts. You should contact your doctor if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Also seek immediate medical attention if you experience signs and symptoms that may suggest heart problems such as coughing, difficulty breathing, fluid retention, swelling, chest pain, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

You may experience reduced absorption of SORAfenib in the presence of food. Take SORAfenib on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. This will make it easier for your body to absorb the medication.