Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- didanosine
- nelfinavir
Interactions between your drugs
didanosine nelfinavir
Applies to: didanosine, nelfinavir
ADJUST DOSING INTERVAL: Nelfinavir should be administered with food, which may adversely affect the absorption of didanosine during concurrent administration due to increased acid in the stomach induced by food intake.
MANAGEMENT: Nelfinavir should be taken with food at least two hours before or one hour after didanosine.
References (1)
- (2001) "Product Information. Viracept (nelfinavir)." Agouron Pharma Inc
Drug and food interactions
didanosine food
Applies to: didanosine
ADJUST DOSING INTERVAL: Didanosine bioavailability is decreased when administered with food. Loss of efficacy may result.
MANAGEMENT: Didanosine should be administered in the fasting state, at least 30 minutes before or more than 2 hours after eating.
References (1)
- (2002) "Product Information. Videx (didanosine)." Bristol-Myers Squibb
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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