Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dapsone
- Primsol (trimethoprim)
Interactions between your drugs
dapsone trimethoprim
Applies to: dapsone, Primsol (trimethoprim)
MONITOR: Serum levels of both trimethoprim and dapsone may be increased during coadministration. The mechanism is unknown. Steady state levels are reached within approximately one week.
MANAGEMENT: When these agents are coadministered, monitoring for methemoglobinemia may be important, especially in patients with respiratory insufficiency, anemia, or cardiovascular disease.
References (4)
- Lee B, Medina I, Benowitz N, et al. (1989) "Dapsone, trimethoprim, and sulfamethoxazole plasma levels during treatment of pneumocystis pneumonia in patients with the acquired immunodeficiency syndrome (AIDS)." Ann Intern Med, 110, p. 606-11
- McKinsey D, Durfee D, Kurtin P (1989) "Megaloblastic pancytopenia associated with dapsone and trimethorprim treatment of pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome." Arch Intern Med, 149, p. 965
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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