Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- colesevelam
- obeticholic acid
Interactions between your drugs
colesevelam obeticholic acid
Applies to: colesevelam, obeticholic acid
ADJUST DOSING INTERVAL: Because bile acid sequestrants adsorb and reduce bile acid absorption, they may reduce the bioavailability and efficacy of obeticholic acid during concomitant administration.
MANAGEMENT: When used with a bile acid sequestrant, obeticholic acid should be administered at least 4 hours before or 4 hours after dosing of the bile acid sequestrant, or at as great an interval as possible.
References (1)
- (2016) "Product Information. Ocaliva (obeticholic acid)." Intercept Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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