Drug Interaction Report

After using chloramphenicol ophthalmic, some of the medication may be absorbed into the bloodstream and may increase the risk of side effects that affect your bone marrow function, resulting in low numbers of different types of blood cells. Using chloramphenicol ophthalmic together with sirolimus may further increase those risks. You may be more likely to develop anemia, bleeding problems or infections due to low blood cell counts. Although serious side effects are not very common with medications administered to the eyes, ears, or vagina because only limited amounts of the medication generally get absorbed into the bloodstream, they can sometimes occur. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need more frequent monitoring to safely use both medications. You should seek medical attention if you develop paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. Also, you should preferably take sirolimus at least one hour before eating. If you do take it with food, you should take it each time with food to avoid changes in sirolimus levels. The oral liquid form of sirolimus must be mixed with water or orange juice only. Do not use grapefruit juice to mix this medication.