Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- carboplatin
- fosphenytoin
Interactions between your drugs
CARBOplatin fosphenytoin
Applies to: carboplatin, fosphenytoin
MONITOR: Carboplatin may decrease serum phenytoin levels. Loss of seizure control may result. The mechanism of this interaction is unknown. It is not know if carboplatin will interact in a similar manner with other hydantoins.
MANAGEMENT: If carboplatin and phenytoin must be used together, close clinical and laboratory observation for evidence of altered phenytoin effect is recommended. Patients should be advised to notify their caregiver if they experience loss of seizure control.
References (1)
- Dofferhoff AS, Berendsen HH, Naalt J, et al. (1990) "Decreased phenytoin level after carboplatin treatment." Am J Med, 89, p. 247-8
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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