Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- carbidopa
- droxidopa
Interactions between your drugs
carbidopa droxidopa
Applies to: carbidopa, droxidopa
MONITOR: Coadministration with dopa-decarboxylase inhibitors such as carbidopa may reduce the therapeutic efficacy of droxidopa, which is directly metabolized in vivo to norepinephrine via decarboxylation. Droxidopa is believed to exert its pharmacological effects through norepinephrine and not through the parent molecule or other metabolites.
MANAGEMENT: Dosage adjustments for droxidopa may be required during coadministration with dopa-decarboxylase inhibitors if an interaction is suspected.
References (1)
- (2014) "Product Information. Northera (droxidopa)." Chelsea Therapeutics Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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