Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR: The administration of SARS-CoV-2 (COVID-19) vaccines to immunosuppressed patients is generally safe, but may be associated with a diminished or suboptimal immunologic response due to antibody inhibition. Observational studies in adults who completed a 1 or 2 dose COVID-19 vaccine series revealed lower efficacy against SARS-CoV-2 infection and COVID-19 disease in immunocompromised adults when compared with the general population. Such patients may include those who have recently received or are receiving immunosuppressive agents, antilymphocyte globulins, alkylating agents, antimetabolites, radiation, some antirheumatic agents, high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than or equal to 2 mg/kg/day or 20 mg/day of prednisone or equivalent for 14 consecutive days or more), or long-term topical or inhaled corticosteroids.

MANAGEMENT: In general, the U.S. Advisory Committee on Immunization Practices (ACIP) recommends administering SARS-CoV-2 (COVID-19) vaccines to moderately or severely immunosuppressed patients. However, depending on the patient's age, concurrent medical condition(s), medication(s), and prior receipt of a COVID-19 vaccine, additional doses, boosters, or revaccination may be appropriate to improve the patient's immune response and the vaccine's efficacy. Whenever possible, COVID-19 vaccine administration should be completed at least 2 weeks before initiation or resumption of immunosuppressive therapies. Revaccination is often recommended in patients who received 1 or more doses of a COVID-19 vaccine prior to or during hematopoietic cell transplantation (HCT) or chimeric antigen receptor (CAR) T-cell therapy and may be considered in patients who were treated with B-cell-depleting therapy over a limited period (e.g., as part of a treatment regimen for certain malignancies). The ACIP recommends that patients who receive B-cell-depleting therapies on a continuing basis receive their COVID-19 vaccine(s) approximately 4 weeks before the next scheduled therapy. COVID-19 vaccines may generally be administered to patients receiving corticosteroids as replacement therapy (e.g., for Addison's disease). Decisions to alter the schedule or frequency of immunosuppressive therapy in order to complete COVID-19 vaccination should consider the individual's risks relative to their underlying condition. Prescribing information and relevant guidelines should be consulted for the most up to date information.

Consumer information for this interaction is not currently available.

MONITOR: Smoking during treatment with deuruxolitinib may increase the risk of major adverse cardiovascular events (MACE) and the risk of developing malignancies. In clinical studies of deuruxolitinib, individuals who were current or former smokers had an additional increased risk of overall malignancies. Also, deuruxolitinib may increase patients' risk of MACE, including myocardial infarction, stroke, and cardiovascular death.

MANAGEMENT: Caution is advised if deuruxolitinib is prescribed to current or past smokers. Patients should be informed about the symptoms of serious cardiovascular events and the steps to take if they occur. The manufacturer recommends discontinuing deuruxolitinib in patients that have experienced a myocardial infarction or stroke. Deuruxolitinib may be taken with or without food.