Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- efbemalenograstim alfa
- Zynteglo (betibeglogene autotemcel)
Interactions between your drugs
betibeglogene autotemcel efbemalenograstim alfa
Applies to: Zynteglo (betibeglogene autotemcel), efbemalenograstim alfa
ADJUST DOSING INTERVAL: Granulocyte-colony stimulating factor (G-CSF) may interact with betibeglogene autotemcel. The mechanism has not been established. Hematopoietic stem cell (HSC) mobilization followed by apheresis to obtain CD34+ cells is required for betibeglogene autotemcel manufacturing. In two ongoing Phase 3 studies, G-CSF and plerixafor were used to mobilize stem cells prior to apheresis and were not recommended within 21 days after betibeglogene autotemcel infusion; however, 24% of patients in these studies received G-CSF within this 21-day period. No data are currently available for this interaction.
MANAGEMENT: According to the manufacturer, G-CSF is not recommended for 21 days after betibeglogene autotemcel infusion.
References (1)
- (2022) "Product Information. Zynteglo (betibeglogene autotemcel)." bluebird bio
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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