Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- busulfan
- exagamglogene autotemcel
Interactions between your drugs
busulfan exagamglogene autotemcel
Applies to: busulfan, exagamglogene autotemcel
ADJUST DOSING INTERVAL: Concurrent use of the autologous genome edited hematopoietic stem cell-based gene therapy exagamglogene autotemcel with myeloablative conditioning agents, such as busulfan, may lead to destruction of the newly edited stem cells. However, clinical data on the use of exagamglogene autotemcel before elimination of the myeloablative conditioning regimen are not available.
MANAGEMENT: The manufacturer recommends administering exagamglogene autotemcel between a minimum of 48 hours and a maximum of 7 days after the last dose of the myeloablative conditioning regimen, to allow for the elimination of the myeloablative conditioning agent from the body.
References (2)
- (2023) "Product Information. Casgevy (exagamglogene autotemcel)." Vertex Pharmaceuticals
- Vertex Pharmaceuticals (Europe) Limited (2024) Casgevy 4-13 x 10Exp6 cells/mL dispersion for infusion https://www.medicines.org.uk/emc/product/15296
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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