Drug Interaction Report
1 drug interaction and 8 additional warnings found for the following 2 drugs:
- adagrasib
- AlphaBath (lanolin / mineral oil topical)
Drug interactions
Moderate drug interactions
Moderate:mineral oil adagrasib
Applies to: AlphaBath (lanolin / mineral oil topical), adagrasib
Adagrasib can cause an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect.
The risk is increased if you have:
- a heart condition called congenital long QT syndrome
- other cardiac diseases
- conduction abnormalities
- electrolyte disturbances, such as low blood levels of magnesium or potassium
These electrolyte disturbances can occur with bowel cleansing preparations or excessive use of medications that have a laxative effect, such as mineral oil.
Do not exceed the dose and duration recommended on the product label or prescribed by your doctor.
You should seek immediate medical attention if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether taken together or separately.
In addition, you should let your doctor know if you experience signs and symptoms of low magnesium or potassium blood level such as:
- weakness
- tiredness
- drowsiness
- dizziness
- confusion
- tingling
- numbness
- muscle pain
- cramps
- nausea
- vomiting
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Major food/lifestyle interactions
Major:Food/Lifestyle adagrasib
Applies to: adagrasib
You should avoid consumption of grapefruit and grapefruit juice during approximately the first 8 days of treatment with adagrasib. During this time, grapefruit juice may increase the blood levels of adagrasib.
This may increase the risk of side effects such as:
- diarrhea
- fatigue
- musculoskeletal pain
- hepatotoxicity
- renal impairment
- an irregular heart rhythm that may be serious and potentially life-threatening
You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with adagrasib.
Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Moderate food/lifestyle interactions
Moderate:multivitamins with minerals mineral oil
Applies to: AlphaBath (lanolin / mineral oil topical)
Using mineral oil together with multivitamins with minerals may decrease the effects of multivitamins with minerals.
Multivitamins with minerals should be administered at least 1 to 2 hours before or 4 to 6 hours after mineral oil.
This interaction does not apply to topical mineral oil.
If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
6 potential interactionsApplies to: 6 conditions, including Inflammatory Bowel Disease, Long QT Syndrome, Bleeding Disorder, Appendicitis, and Gastrointestinal Obstruction.
Appendicitis
Major:AlphaBath
The mineral oil in AlphaBath has a major potential interaction with Appendicitis.
The use of stimulant laxatives is contraindicated in patients with or who may have acute surgical abdomen or appendicitis. These patients may be candidates for emergency surgery. Stimulant laxatives should also not be administered to patients with abdominal pain, particularly if the cause has not been determined.
Bleeding Disorder
Major:AlphaBath
The mineral oil in AlphaBath has a major potential interaction with Bleeding Disorder.
The use of stimulant laxatives is contraindicated in patients with anal or rectal fissures. These preparations may cause irritation, burning sensation, and proctitis.
Gastrointestinal Obstruction
Major:AlphaBath
The mineral oil in AlphaBath has a major potential interaction with Gastrointestinal Obstruction.
The use of laxatives is contraindicated in patients with intestinal obstruction disorders. Patients with intestinal obstruction disorders may need their underlying condition treated to correct the constipation. Some laxatives require reduction in the colon to their active form to be effective which may be a problem in patients with intestinal obstruction.
Inflammatory Bowel Disease
Major:AlphaBath
The mineral oil in AlphaBath has a major potential interaction with Inflammatory Bowel Disease.
The use of laxatives is contraindicated in patients with inflammatory bowel disease. Patients with inflammatory bowel disease may experience colonic perforation with use of stimulant laxatives.
Long QT Syndrome
Moderate:adagrasib
Adagrasib has a moderate potential interaction with Long QT Syndrome.
Adagrasib can cause QTc prolongation, which increases the risk of ventricular tachyarrhythmias or sudden death. Use should be avoided in patients with congenital long QT syndrome, in patients with concurrent QTc prolongation, and patients taking other medicines known to prolong the QTc interval. Monitor ECG and electrolytes prior to starting treatment and as indicated during therapy.
Pulmonary Impairment
Moderate:adagrasib
Adagrasib has a moderate potential interaction with Pulmonary Impairment.
Adagrasib can cause interstitial lung disease (ILD)/pneumonitis which can be fatal. Patients should be monitored for new or worsening symptoms indicative of ILD/pneumonitis during treatment. Caution is advised in patients with pulmonary impairment.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.