Drug Interaction Report
1 drug interaction and 4 additional warnings found for the following 2 drugs:
- asciminib
- histoplasmin
Drug interactions
Moderate drug interactions
Moderate:histoplasmin asciminib
Applies to: histoplasmin, asciminib
If you are currently being treated or have recently been treated with asciminib, you should let your doctor know before receiving histoplasmin.
Depending on the dose and length of time you have been on asciminib, you may have a reduced response to the skin test.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Food/lifestyle interactions
Moderate food/lifestyle interactions
Moderate:Food/Lifestyle asciminib
Applies to: asciminib
Food may reduce the absorption of asciminib, which may lead to lower blood levels of the medication and possibly reduced effectiveness.
What to do: You should avoid eating for at least 2 hours before and 1 hour after taking asciminib.
Talk to your doctor or pharmacist if you have questions on how to take this or other medications you are prescribed.
It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Disease interactions
3 potential interactionsApplies to: 3 conditions, including High Blood Pressure, Pancreatitis, and Cardiovascular Conditions and Disorders.
Cardiovascular Conditions and Disorders
Major:asciminib
Asciminib has a major potential interaction with Cardiovascular Conditions and Disorders.
Cardiovascular toxicity has been reported with asciminib in patients with preexisting cardiovascular conditions or risk factors for cardiovascular disease. Reports of cardiovascular toxicity have included ischemia, arterial thrombotic and embolic conditions, and cardiac failure. Arrhythmia, including QTc prolongation, has been reported. Monitor patients with history of cardiovascular risk factors for cardiovascular signs and symptoms. Treat as clinically indicated. For cardiovascular toxicity, temporarily withhold, reduce dose, or permanently discontinue therapy, based on persistence of cardiovascular toxicity.
High Blood Pressure
Moderate:asciminib
Asciminib has a moderate potential interaction with High Blood Pressure.
The use of asciminib may cause hypertension. Blood pressure should be well-controlled prior to initiating asciminib and treated as needed with standard anti-hypertensive therapy. For persistent hypertension despite anti-hypertensive medications, temporarily withhold, reduce dose, or permanently discontinue therapy, based on the persistence of hypertension.
Pancreatitis
Major:asciminib
Asciminib has a major potential interaction with Pancreatitis.
Asciminib can cause increases in serum lipase. Patients with a previous history of pancreatitis might be at increased risk and should be monitored carefully for lipase elevations and any abdominal symptoms. Serum lipase should be monitored monthly and as clinically indicated. If lipase and amylase elevations are accompanied by abdominal symptoms, hold therapy, and rule out pancreatitis.
Report options
- Switch to professional interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.