Drug Interaction Report
5 potential interactions and/or warnings found for the following 2 drugs:
- cabotegravir
- Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e)
Interactions between your drugs
calcium carbonate cabotegravir
Applies to: Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e), cabotegravir
Calcium carbonate may interfere with the absorption of cabotegravir (brand name Vocabria) when they are taken orally at the same time or too close together. You should take calcium carbonate at least 2 hours before or 4 hours after the cabotegravir dose. Talk to your doctor or pharmacist if you have any questions on how to use these medications properly. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
melatonin valerian
Applies to: Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e), Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e)
Using melatonin together with valerian may increase side effects such as dizziness, drowsiness, confusion, and difficulty concentrating. Some people, especially the elderly, may also experience impairment in thinking, judgment, and motor coordination. You should avoid or limit the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
calcium carbonate food
Applies to: Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e)
Calcium absorption may be increased by taking it with food. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption. Calcium may be taken with food to increase absorption. Consider spacing calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
melatonin food
Applies to: Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e)
Both smoking and excessive caffeine consumption can alter the blood levels of melatonin, which may affect the dosing. Tobacco smoking reduces, while caffeine increases melatonin blood levels. If you start smoking or undergo smoking cessation, your doctor may need to adjust the dose of melatonin. In addition, alcohol may reduce the effect of melatonin on sleep. It is best to avoid alcohol consumption during melatonin therapy. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
valerian food
Applies to: Natrol Sleep'n Restore (calcium carbonate / melatonin / valerian / vitamin e)
Alcohol can increase the nervous system side effects of valerian such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with valerian. Do not use more than the recommended dose of valerian, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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