Drug Interaction Report

Palbociclib may increase the blood levels of the active medication in enfortumab vedotin in some patients. This may increase the risk and/or severity of side effects such as nausea; vomiting; diarrhea; loss of appetite; tingling, numbness or burning in the hands and feet; muscle weakness; hyperglycemia (high blood sugar); skin reactions (rash, itching, hair loss); lung problems (trouble breathing, shortness of breath, cough); eye disorders (dry eyes, inflammation of the cornea, blurred vision); and low platelet and white blood cell counts. You may also be more likely to develop bleeding problems or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Palbociclib oral capsules (Ibrance) should be taken with food to help with its absorption. Palbociclib oral tablets (Ibrance) may be taken with or without food. Do not consume grapefruit or grapefruit juice during treatment with palbociclib. Grapefruit and grapefruit juice can interact with palbociclib and increase the levels of palbociclib in your body. You may be more likely to experience side effects such as nausea; vomiting; diarrhea; loss of appetite; mouth sores; hair loss; weakness; pain, numbness, or tingling in the hands and feet; and impaired bone marrow function resulting in low numbers of different types of blood cells, which can increase the risk of anemia, bleeding problems, and infections. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.