Drug Interaction Report

Nilotinib may increase the blood levels of the active medication in enfortumab vedotin in some patients. This may increase the risk and/or severity of side effects such as nausea; vomiting; diarrhea; loss of appetite; tingling, numbness or burning in the hands and feet; muscle weakness; hyperglycemia (high blood sugar); skin reactions (rash, itching, hair loss); lung problems (trouble breathing, shortness of breath, cough); eye disorders (dry eyes, inflammation of the cornea, blurred vision); and low platelet and white blood cell counts. You may also be more likely to develop bleeding problems or infections due to low blood cell counts. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Do not consume grapefruit or grapefruit juice during treatment with nilotinib unless directed otherwise by your doctor. Grapefruit juice can increase the blood levels of nilotinib to dangerous levels, increasing the risk of an irregular heart rhythm that may be serious. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with nilotinib. Food may also increase the blood levels of nilotinib. Therefore, you should take nilotinib on an empty stomach, meaning no food should be eaten for at least two hours before or one hour after taking nilotinib. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.