Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- bosentan
- Provigil (modafinil)
Interactions between your drugs
modafinil bosentan
Applies to: Provigil (modafinil), bosentan
MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of modafinil (the racemate) and armodafinil (the R-enantiomer), which are both partially metabolized by the isoenzyme.
MANAGEMENT: Pharmacologic response to modafinil or armodafinil should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy. Dose adjustments may be required if an interaction is suspected.
References (6)
- Robertson P, Decory HH, Madan A, Parkinson A (2000) "In vitro inhibition and induction of human hepatic cytochrome P450 enzymes by modafinil." Drug Metab Dispos, 28, p. 664-71
- (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc
- (2024) "Product Information. Modafinil (modafinil)." Milpharm Ltd
- (2023) "Product Information. Modafinil (Apo) (modafinil)." Apotex Pty Ltd
- (2024) "Product Information. Apo-Modafinil (modafinil)." Apotex Incorporated
- (2024) "Product Information. Modafinil (modafinil)." Heritage Pharmaceuticals Inc
Drug and food interactions
modafinil food
Applies to: Provigil (modafinil)
Administration with food may delay the absorption of modafinil (the racemate) and armodafinil (the R-enantiomer) without significantly affecting their overall bioavailability. According to the product labeling, modafinil's absorption may be delayed by approximately one hour if taken with food. Similarly, the time to reach peak plasma concentration (Tmax) of armodafinil may be delayed by approximately 2 to 4 hours in the fed state.
References (2)
- (2001) "Product Information. Provigil (modafinil)." Cephalon, Inc
- (2007) "Product Information. Nuvigil (armodafinil)." Cephalon Inc
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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