Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- dorzolamide / latanoprost / timolol ophthalmic
- methacholine
Interactions between your drugs
methacholine timolol ophthalmic
Applies to: methacholine, dorzolamide / latanoprost / timolol ophthalmic
CONTRAINDICATED: Patients who are concurrently receiving beta blockers may have exaggerated or prolonged responses (i.e., bronchoconstriction) to methacholine challenge and may not respond readily to treatment. Beta-2-adrenergic blockade increases airway resistance. Ophthalmically applied beta blockers undergo some systemic absorption and potentially may also interact.
MANAGEMENT: Administration of methacholine to a patient on any beta blocker therapy is considered contraindicated.
References (1)
- (2002) "Product Information. Provocholine (methacholine)." Methapharm Inc
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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