Drug Interaction Report

MONITOR: Coadministration with trofinetide may increase the plasma concentrations of drugs that are substrates of organic anion transporting polypeptide 1B1 (OATP1B1) and/or 1B3 (OATP1B3) via inhibition of these transporters. Clinical and pharmacokinetic data are currently lacking.

MANAGEMENT: Caution is advised if trofinetide is used concomitantly with substrates of OATP1B1 or OATP1B3, particularly sensitive substrates or those with a narrow therapeutic range. The prescribing information for trofinetide recommends avoiding coadministration with OATP1B1/3 substrates for which minimal concentration changes may lead to serious toxicities. If coadministration is required, dosage adjustments as well as clinical and laboratory monitoring may be appropriate whenever trofinetide is added to or withdrawn from therapy. The prescribing information for concomitant medications should be consulted to assess the benefits versus risks of coadministration and for any dosage adjustments that may be required.

ADJUST DOSING INTERVAL: Food enhances the oral bioavailability of glecaprevir and pibrentasvir. Relative to fasting conditions, mean glecaprevir systemic exposure (AUC) increased by 83% to 163% and mean pibrentasvir AUC increased by 40% to 53% when administered with moderate to high fat meals.

MANAGEMENT: Glecaprevir-pibrentasvir should be administered with food.