Drug Interaction Report
4 potential interactions and/or warnings found for the following 2 drugs:
- Bicillin C-R 900/300 (penicillin g benzathine / procaine penicillin)
- sodium iodide-i-131
Interactions between your drugs
sodium iodide I-131 procaine penicillin
Applies to: sodium iodide-i-131, Bicillin C-R 900/300 (penicillin g benzathine / procaine penicillin)
ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.
MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.
References (1)
- (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare
sodium iodide I-131 penicillin G benzathine
Applies to: sodium iodide-i-131, Bicillin C-R 900/300 (penicillin g benzathine / procaine penicillin)
ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.
MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.
References (1)
- (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare
Drug and food interactions
sodium iodide I-131 food
Applies to: sodium iodide-i-131
MONITOR: Excessive intake of dietary iodine (e.g., iodised salt) may interfere with adequate uptake of radioiodide by the thyroid .
MANAGEMENT: A diet low in iodine is recommended before initiating therapy with sodium iodide I-131 or I-123.
References (1)
- Cerner Multum, Inc. "Australian Product Information."
sodium iodide I-131 food
Applies to: sodium iodide-i-131
ADJUST DOSING INTERVAL: Certain drugs may affect the pharmacokinetics, pharmacodynamics, and/or diagnostic results of radioiodides.
MANAGEMENT: Antithyroid agents such as carbimazole or propylthiouracil should generally be withheld for 1 week before administration of sodium iodide I-131 or I-123, and for a few days afterward. Salicylates, steroids, anticoagulants, antihistamines, antiparasitics, penicillins, sulfonamides, tolbutamide, thiopental, and nitroprusside should generally be withheld for 1 week. Amiodarone, lithium, and benzodiazepines should be withheld for at least 4 weeks.
References (1)
- (2022) "Product Information. Sodium Iodide I-123 (sodium iodide I-123)." GE Healthcare
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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