Drug Interaction Report

Ritonavir can significantly increase the blood levels of daclatasvir. This may increase the risk and/or severity of side effects such as headache, fatigue, nausea, and diarrhea. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the interaction, but has determined that this is the best course of treatment for you and has taken appropriate precautions or made dose adjustments and is monitoring you closely for any potential complications. Your doctor may also be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Ritonavir should be taken with food to lessen gastrointestinal side effects. It is important that you take this medication exactly as prescribed by your doctor. Do not change your treatment or stop treatment without first talking to your doctor.

Food significantly increases the absorption of paritaprevir. You should take each dose of paritaprevir with a meal. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.

The recommended maximum number of medicines in the 'NS5A inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'NS5A inhibitors' category:

• Daklinza (daclatasvir)
• Viekira XR (dasabuvir / ombitasvir / paritaprevir / ritonavir)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.