Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Harvoni (ledipasvir / sofosbuvir)
- magnesium carbonate
Interactions between your drugs
magnesium carbonate ledipasvir
Applies to: magnesium carbonate, Harvoni (ledipasvir / sofosbuvir)
ADJUST DOSING INTERVAL: Concurrent administration of ledipasvir with drugs that elevate gastric pH such as antacids may reduce its gastrointestinal absorption. Ledipasvir exhibits pH-dependent solubility, with increased solubility at lower pH. Drugs that increase gastric pH are expected to decrease the plasma concentration of ledipasvir.
MANAGEMENT: If an antacid is required, the antacid should be taken 4 hours before or 4 hours after administration of ledipasvir-sofosbuvir. The same precaution may be applicable to other drugs with antacid effects.
References (1)
- (2014) "Product Information. Harvoni (ledipasvir-sofosbuvir)." Gilead Sciences
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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