Drug Interaction Report

Talk to your doctor before using doxylamine together with donepezil. Medications like doxylamine may reduce the effectiveness of donepezil. In addition, patients with Alzheimer's disease or other dementia may be more likely to experience nervous system side effects of doxylamine such as drowsiness, confusion, and mental impairment. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of doxylamine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with doxylamine. Do not use more than the recommended dose of doxylamine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.