Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- clotrimazole
- daclatasvir
Interactions between your drugs
clotrimazole daclatasvir
Applies to: clotrimazole, daclatasvir
MONITOR: Coadministration with moderate inhibitors of CYP450 3A4 may increase the plasma concentrations of daclatasvir, which is primarily metabolized by the isoenzyme. When a single 10 mg dose of daclatasvir was administered following pretreatment with the potent CYP450 3A4 inhibitor ketoconazole (400 mg once daily), daclatasvir peak plasma concentration (Cmax) and systemic exposure (AUC) increased by 1.6- and 3-fold, respectively. No data are available for other, less potent CYP450 3A4 inhibitors.
MANAGEMENT: Caution is advised when daclatasvir is used with moderate CYP450 3A4 inhibitors; however, according to the manufacturer, dose adjustments are not required. Patients should be monitored for adverse effects such as headache, fatigue, nausea, diarrhea, and serum lipase elevations.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2015) "Product Information. Daklinza (daclatasvir)." Bristol-Myers Squibb
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Diflucan
Diflucan (fluconazole) is used to treat and prevent fungal infections. Includes Diflucan side ...
Acidophilus
Acidophilus helps maintain an acidic environment, which can prevent the growth of harmful bacteria ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Mycostatin
Mycostatin is used for gastrointestinal candidiasis, oral thrush
Sporanox
Sporanox (itraconazole) is used to treat fungal infections of the lungs, mouth, throat, toenails ...
Florajen
Florajen is used for clostridioides difficile infection, diarrhea, irritable bowel syndrome, oral ...
Intestinex
Intestinex is used for clostridioides difficile infection, diarrhea, irritable bowel syndrome, oral ...
Acidophilus Probiotic Blend
Acidophilus Probiotic Blend is used for clostridioides difficile infection, diarrhea, irritable ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.