Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- polymyxin b
- tubocurarine
Interactions between your drugs
polymyxin B sulfate tubocurarine
Applies to: polymyxin b, tubocurarine
GENERALLY AVOID: Polymyxin B may prolong apnea and respiratory paralysis after use of neuromuscular blocking agents. The mechanism may be related to decreased intracellular potassium or decreased ionized serum calcium. Intravenous calcium administration may be helpful in reversing the paralysis.
MANAGEMENT: This combination should be avoided unless the benefit outweighs the risk. Patients should be closely monitored for signs of extended neuromuscular blockade.
References (3)
- Levine RA, Beiber MP, Forte FA, et al. (1969) "Polymyxin B-induced respiratory paralysis reversed by intravenous calcium chloride." J Mt Sinai Hosp N Y, 36, p. 380-7
- Fogdall RP, Miller RD (1974) "Prolongation of a pancuronium-induced neuromuscular blockade by polymyxin B." Anesthesiology, 40, p. 84-7
- (2001) "Product Information. Raplon (rapacuronium)." Organon
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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