Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- atracurium
- MagDelay (calcium carbonate / magnesium chloride)
Interactions between your drugs
atracurium magnesium chloride
Applies to: atracurium, MagDelay (calcium carbonate / magnesium chloride)
MONITOR: Magnesium salts may enhance the effects of nondepolarizing neuromuscular blocking agents. One study showed a 25% increase in vecuronium potency after intravenous administration of 40 mg/kg of magnesium sulfate.
MANAGEMENT: Patients should be closely monitored for excessive or prolonged neuromuscular blockade and ventilatory support should be immediately available.
References (2)
- (2001) "Product Information. Norcuron (vecuronium)." Organon
- Fuchs-Buder T, Wilder-Smith OH, Borgeat A, Tassonyi E (1995) "Interaction of magnesium sulphate with vecuronium-induced neuromuscular block." Br J Anaesth, 74, p. 405-9
Drug and food interactions
calcium carbonate food
Applies to: MagDelay (calcium carbonate / magnesium chloride)
ADJUST DOSING INTERVAL: Administration with food may increase the absorption of calcium. However, foods high in oxalic acid (spinach or rhubarb), or phytic acid (bran and whole grains) may decrease calcium absorption.
MANAGEMENT: Calcium may be administered with food to increase absorption. Consider withholding calcium administration for at least 2 hours before or after consuming foods high in oxalic acid or phytic acid.
References (6)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Canadian Pharmacists Association (2006) e-CPS. http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink
- Cerner Multum, Inc. "Australian Product Information."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- Mangels AR (2014) "Bone nutrients for vegetarians." Am J Clin Nutr, 100, epub
- Davies NT (1979) "Anti-nutrient factors affecting mineral utilization." Proc Nutr Soc, 38, p. 121-8
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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