Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Hivid (zalcitabine)
- pentamidine
Interactions between your drugs
pentamidine zalcitabine
Applies to: pentamidine, Hivid (zalcitabine)
GENERALLY AVOID: Coadministration of intravenous pentamidine with didanosine or zalcitabine may increase the risk of pancreatitis. These drugs have individually been associated with pancreatitis and additive toxicity may occur during concomitant use. Fatalities have been reported.
MANAGEMENT: The manufacturer recommends that the antiretroviral drugs should be interrupted, if clinically feasible, when treatment with intravenous pentamidine is initiated. If concomitant use cannot be avoided, patients should be closely monitored for clinical and laboratory signs of pancreatitis.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
Drug and food interactions
zalcitabine food
Applies to: Hivid (zalcitabine)
Zalcitabine bioavailability may be decreased by 14% if taken with meals. The mechanism and clinical significance are unknown.
References (1)
- (2001) "Product Information. HIVID (zalcitabine)." Roche Laboratories
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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