Drug Interaction Report

High doses of anticholinergic agents may attenuate the response to secretin and cause false-positive results. Anticholinergics inhibit gastric acid secretion. Clinicians should be aware of the potential for inaccurate test results when administering secretin to patients treated with anticholinergic drugs.

ADJUST DOSING INTERVAL: Food may reduce the oral absorption and bioavailability of trospium chloride. According to the product labeling, administration of trospium chloride with a high fat meal reduced the peak plasma concentration (Cmax) and area under the concentration-time curve (AUC) by 70% to 80% compared to administration while fasting.

MANAGEMENT: To ensure maximal oral absorption, trospium chloride should be administered at least 1 hour before meals or on an empty stomach. If trospium chloride is administered as a combination with xanomeline, the manufacturer recommends administering the capsules at least 1 hour before a meal or at least 2 hours after a meal. Capsules should be taken whole.