Drug Interaction Report

Saquinavir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Velpatasvir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food can enhance the levels of saquinavir in your body. Saquinavir should be taken with meals or within 2 hours after eating. This will make it easier for your body to absorb the medication. Grapefruit can raise the levels of saquinavir in your body. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Food may help the absorption of voxilaprevir. You should take this medication with food as directed.

The recommended maximum number of medicines in the 'protease inhibitors' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'protease inhibitors' category:

• saquinavir
• Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.