Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Crestor (rosuvastatin)
- tivozanib
Interactions between your drugs
rosuvastatin tivozanib
Applies to: Crestor (rosuvastatin), tivozanib
MONITOR: Coadministration with tivozanib may increase the plasma concentrations and therapeutic effects of drugs that are substrates of the breast cancer resistance protein (BCRP) transporter. The proposed mechanism, based on in vitro data, is decreased clearance due to inhibition of BCRP-mediated intestinal efflux by tivozanib. The clinical significance of this interaction has not been established; however, it should be taken into consideration with orally administered intestinal BCRP-sensitive substrates such as rosuvastatin.
MANAGEMENT: Caution and clinical monitoring are advised if tivozanib is prescribed with orally administered drugs that are sensitive substrates for BCRP, such as rosuvastatin. If coadministration is necessary, the manufacturer suggests separating the administration times by 2 or more hours.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- (2021) "Product Information. Fotivda (tivozanib)." Aveo Pharmaceuticals, Inc.
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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