Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Benemid (probenecid)
- zalcitabine
Interactions between your drugs
probenecid zalcitabine
Applies to: Benemid (probenecid), zalcitabine
MONITOR: Probenecid may increase plasma concentrations and decrease clearance of zalcitabine. The mechanism may be inhibition of renal tubular secretion of zalcitabine.
MANAGEMENT: Close clinical monitoring for evidence of zalcitabine toxicity (peripheral neuropathy, pancreatitis, lactic acidosis, hepatotoxicity) is recommended when these drugs are used together. In addition, a reduction in zalcitabine dosage may be warranted. Patients should be advised to promptly notify their physician if they experience numbness, tingling, severe nausea and vomiting, diarrhea, abdominal pain, severe fatigue, jaundice, or unusual bleeding or bruising.
References (1)
- Massarella JW, Nazareno LA, Passe S, Min B (1996) "The effect of probenecid on the pharmacokinetics of zalcitabine in HIV-positive patients." Pharmaceut Res, 13, p. 449-52
Drug and food/lifestyle interactions
zalcitabine food/lifestyle
Applies to: zalcitabine
Zalcitabine bioavailability may be decreased by 14% if taken with meals. The mechanism and clinical significance are unknown.
References (1)
- (2001) "Product Information. HIVID (zalcitabine)." Roche Laboratories
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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