Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Benemid (probenecid)
- valacyclovir
Interactions between your drugs
probenecid valACYclovir
Applies to: Benemid (probenecid), valacyclovir
Probenecid may increase the serum concentration of acyclovir through competitive inhibition of renal tubular secretion. Initial dosage adjustments are not usually necessary, but patients should be monitored for acyclovir-related toxicities. Also, probenecid reduces the rate at which valacyclovir is converted to acyclovir. The extent of conversion, however, is unaffected. This interaction is not considered to be clinically significant.
References (3)
- Laskin OL, de Miranda P, King DH, et al. (1982) "Effects of probenecid on the pharmacokinetics and elimination of acyclovir in humans." Antimicrob Agents Chemother, 21, p. 804-7
- (2001) "Product Information. Valtrex (valacyclovir)." Glaxo Wellcome
- Rolan PE, Maillot F, On NT, Posner J (1993) "The effects of cimetidine and probenecid on the conversion of a valine ester of acyclovir, 256U, to acyclovir and acyclovir renal clearance in healthy volunteers." Br J Clin Pharmacol, 33, p. 533
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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