Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- probenecid
- Uro-Pain Dual Action (methenamine / sodium salicylate)
Interactions between your drugs
probenecid sodium salicylate
Applies to: probenecid, Uro-Pain Dual Action (methenamine / sodium salicylate)
GENERALLY AVOID: Large, anti-inflammatory doses of salicylates may inhibit the uricosuric effect of probenecid. The mechanism of interaction has not been established. In contrast, low, daily antiplatelet doses do not seem to interact. In a study of 11 patients with gouty arthritis receiving a stable dosage of probenecid for at least three months, no significant effects on serum levels or 24-hour urinary excretion of uric acid were observed during coadministration with enteric-coated aspirin 325 mg/day, taken simultaneously with probenecid or 6 hours after.
MANAGEMENT: Large doses of salicylates should be avoided in patients who require probenecid for the treatment of hyperuricemia or gout. However, occasional use of low dosages for analgesia or daily use of cardioprotective dosages should generally not be a concern.
References (4)
- Diamond JS, Paolino JS (1973) "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest, 52, p. 1491-9
- Regal RE (1987) "Aspirin and uricosurics: interaction revisited." Drug Intell Clin Pharm, 21, p. 219-20
- Harris M, Bryant LR, Danaher P, Alloway J (2000) "Effect of low dose daily aspirin on serum urate levels and urinary excretion in patients receiving probenecid for gouty arthritis." J Rheumatol, 27, p. 2873-6
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Zyloprim
Zyloprim is used for calcium oxalate calculi with hyperuricosuria, gout, hyperuricemia secondary to ...
Uloric
Uloric (febuxostat) reduces the production of uric acid in your body and is used to treat gout ...
Mounjaro
Mounjaro is used for type 2 diabetes to help lower blood sugar levels. Mounjaro has also been shown ...
Krystexxa
Krystexxa (pegloticase) is an enzyme that metabolizes uric acid and is used to treat chronic gout ...
Benemid
Benemid is used for adjunct to antibiotic therapy, gout, gouty arthritis
Aloprim
Aloprim is used for calcium oxalate calculi with hyperuricosuria, gout, hyperuricemia secondary to ...
Allopurinol
Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in certain ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.