Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- midodrine
- Uroxatral (alfuzosin)
Interactions between your drugs
midodrine alfuzosin
Applies to: midodrine, Uroxatral (alfuzosin)
GENERALLY AVOID: Midodrine, an alpha agonist, when used in combination with alpha adrenergic blockers may lead to a decreased therapeutic effect in some patients. The mechanism is due to pharmacologic antagonism at the alpha adrenoreceptor.
MANAGEMENT: Alpha adrenergic blockers should be avoided, if possible, in patients taking midodrine for orthostatic hypotension.
References (3)
- (2001) "Product Information. ProAmatine (midodrine)." Roberts Pharmaceutical Corporation
- (2002) "Product Information. Xatral (alfuzosin)." Sanofi-Synthelabo Canada Inc
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
Drug and food/lifestyle interactions
alfuzosin food/lifestyle
Applies to: Uroxatral (alfuzosin)
ADJUST DOSING INTERVAL: Administration of alfuzosin with food enhances oral bioavailability. According to the manufacturer, extent of absorption is 50% higher when administered under fed conditions compared to fasting conditions.
MANAGEMENT: To ensure maximal oral absorption, alfuzosin should be administered with or immediately after a meal.
References (1)
- (2003) "Product Information. Uroxatral (alfuzosin)." sanofi-aventis
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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