Drug Interaction Report

Using opicapone together with methylene blue is not recommended. Combining these medications can cause dangerously high blood pressure and also increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. In general, you should wait at least 14 days after stopping methylene blue before you start treatment with opicapone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food may delay and reduce the absorption of opicapone, which may lead to lower blood levels of the medication and possibly reduced effectiveness. You should take opicapone once daily at bedtime. Do not eat food for at least 1 hour before and at least 1 hour after taking opicapone. Talk to your doctor or pharmacist if you have any questions or concerns.