Drug Interaction Report

MONITOR: The coadministration of nesiritide with intravenous vasodilators such as nitroglycerin, nitroprusside, and milrinone has not been evaluated. Theoretically, an increase in symptomatic hypotension may occur due to possible additive pharmacodynamic effects in the vasculature. A similar risk may exist during coadministration with oral vasodilators such as hydralazine and minoxidil and other agents with vasodilating effects.

MANAGEMENT: Whether used alone or with other agents, nesiritide should be administered only in settings where blood pressure can be closely monitored. The dosage should be reduced or the drug discontinued in patients who develop hypotension.

The recommended maximum number of medicines in the 'non-nitrate vasodilators' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'non-nitrate vasodilators' category:

• isoxsuprine
• nesiritide

Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.