Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- altretamine
- cyanocobalamin / folic acid / pyridoxine / strontium gluconate
Interactions between your drugs
pyridoxine altretamine
Applies to: cyanocobalamin / folic acid / pyridoxine / strontium gluconate, altretamine
GENERALLY AVOID: Data from a randomized trial of altretamine and cisplatin in ovarian cancer indicated that pyridoxine significantly reduced neurotoxicity but also adversely affected response duration. The mechanism of interaction has not been established.
MANAGEMENT: Until further data are available, it may be advisable to avoid using altretamine with pyridoxine.
References (2)
- (2022) "Product Information. Hexalen (altretamine)." US Bioscience
- Wiernik PH, Yeap B, Vogl SE, et al. (1992) "Hexamethylmelamine and low or moderate dose cisplatin with or without pyridoxine for treatment of advanced ovarian carcinoma: a study of the Eastern Cooperative Oncology Group." Cancer Invest, 10, p. 1-9
Drug and food interactions
folic acid food
Applies to: cyanocobalamin / folic acid / pyridoxine / strontium gluconate
MONITOR: Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
MANAGEMENT: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
References (5)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- Cerner Multum, Inc (2015) "ANVISA Bulário Eletrônico."
- (2017) "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC
strontium gluconate food
Applies to: cyanocobalamin / folic acid / pyridoxine / strontium gluconate
ADJUST DOSING INTERVAL: Concomitant administration of strontium with food or milk products may decrease its bioavailability by 60% to 70%.
MANAGEMENT: Strontium salts should be taken at least two hours before or two hours after food or milk products, and preferably at bedtime.
References (1)
- (2007) "Product Information. Bonisara (cyanocobalamin/folic acid/pyridoxine/strontiu)." Zylera Pharamaceuticals
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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