Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- halothane
- LGG (dyphylline / guaifenesin)
Interactions between your drugs
halothane dyphylline
Applies to: halothane, LGG (dyphylline / guaifenesin)
GENERALLY AVOID: The administration of halothane following theophylline administration has been reported to result in ventricular tachycardia and, in one case, ventricular fibrillation. Halothane increases the arrhythmogenic potential of catecholamines. Theophylline appears to enhance the release of catecholamines.
MANAGEMENT: This combination should be avoided if possible. Halothane may interact in a similar manner with other methylxanthines.
References (2)
- Roizen MF, Stevens WC (1978) "Multiform ventricular tachycardia due to the interaction of aminophylline and halothane." Anesth Analg, 57, p. 738-41
- Richards W, Thompson J, Lewis G, et al. (1988) "Cardiac arrest associated with halothane anesthesia in a patient receiving theophylline." Ann Allergy, 61, p. 83-4
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
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Further information
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